Literature DB >> 24709291

The journey towards elimination of gambiense human African trypanosomiasis: not far, nor easy.

J R Franco1, P P Simarro1, A Diarra2, J A Ruiz-Postigo3, J G Jannin1.   

Abstract

Considering the epidemic situation of gambiense human African trypanosomiasis (HAT) at the end of the twentieth century, the World Health Organization (WHO) and partners strengthened disease control and surveillance. Over the last 15 years, the activities implemented through the National Control Programmes have brought gambiense HAT under control and now its elimination is deemed as an achievable goal. In 2012, WHO targeted gambiense HAT for elimination as a public health problem by 2020. The final goal will be the sustainable disease elimination by 2030, defined as the interruption of the transmission of gambiense HAT. The elimination is considered feasible, because of the epidemiological vulnerability of the disease, the current state of control, the availability of strategies and tools and international commitment and political will. Integration of activities in the health system is needed to ensure the sustainability of the elimination. The development of user-friendly diagnostic and treatment tools will facilitate the integration process. Adequate funding is needed to implement activities, but also to support research that will make the elimination sustainable. A long-term commitment by donors is needed and ownership of the process by endemic countries is critical.

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Year:  2014        PMID: 24709291     DOI: 10.1017/S0031182013002102

Source DB:  PubMed          Journal:  Parasitology        ISSN: 0031-1820            Impact factor:   3.234


  46 in total

1.  Sensitivity and Specificity of a Prototype Rapid Diagnostic Test for the Detection of Trypanosoma brucei gambiense Infection: A Multi-centric Prospective Study.

Authors:  Sylvie Bisser; Crispin Lumbala; Etienne Nguertoum; Victor Kande; Laurence Flevaud; Gedeao Vatunga; Marleen Boelaert; Philippe Büscher; Theophile Josenando; Paul R Bessell; Sylvain Biéler; Joseph M Ndung'u
Journal:  PLoS Negl Trop Dis       Date:  2016-04-08

2.  Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.

Authors:  Oleg A Volkov; Anthony J Brockway; Stephen A Wring; Michael Peel; Zhe Chen; Margaret A Phillips; Jef K De Brabander
Journal:  J Med Chem       Date:  2018-01-05       Impact factor: 7.446

3.  Activity of Bisnaphthalimidopropyl Derivatives against Trypanosoma brucei.

Authors:  Nuno A G Graça; Luis Gaspar; David M Costa; Inês Loureiro; Paul Kong Thoo-Lin; Isbaal Ramos; Meritxell Roura; Alain Pruvost; Ian K Pemberton; Hadjer Loukil; Jane MacDougall; Joana Tavares; Anabela Cordeiro-da-Silva
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

4.  N6-methyladenosine in poly(A) tails stabilize VSG transcripts.

Authors:  Juan Pereira de Macedo; Lúcia Serra; Idálio J Viegas; Mariana De Niz; Adriana Temporão; Sara Silva Pereira; Aashiq H Mirza; Ed Bergstrom; João A Rodrigues; Francisco Aresta-Branco; Samie R Jaffrey; Luisa M Figueiredo
Journal:  Nature       Date:  2022-03-30       Impact factor: 69.504

5.  Accuracy of individual rapid tests for serodiagnosis of gambiense sleeping sickness in West Africa.

Authors:  Vincent Jamonneau; Oumou Camara; Hamidou Ilboudo; Moana Peylhard; Mathurin Koffi; Hassane Sakande; Louis N'Dri; Djénéba Sanou; Emilie Dama; Mamadou Camara; Veerle Lejon
Journal:  PLoS Negl Trop Dis       Date:  2015-02-02

6.  On the road to elimination of Rhodesiense human African trypanosomiasis: first WHO meeting of stakeholders.

Authors:  Peter Holmes
Journal:  PLoS Negl Trop Dis       Date:  2015-04-02

7.  Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome.

Authors:  Deuan C Jones; Bernardo J Foth; Michael D Urbaniak; Stephen Patterson; Han B Ong; Matthew Berriman; Alan H Fairlamb
Journal:  PLoS Negl Trop Dis       Date:  2015-12-18

Review 8.  Drug resistance in eukaryotic microorganisms.

Authors:  Alan H Fairlamb; Neil A R Gow; Keith R Matthews; Andrew P Waters
Journal:  Nat Microbiol       Date:  2016-06-24       Impact factor: 17.745

9.  Molecular evidence of a Trypanosoma brucei gambiense sylvatic cycle in the human african trypanosomiasis foci of Equatorial Guinea.

Authors:  Carlos Cordon-Obras; Yasmin Fermin Rodriguez; Amalia Fernandez-Martinez; Jorge Cano; Nicolas Ndong-Mabale; Policarpo Ncogo-Ada; Pedro Ndongo-Asumu; Pilar Aparicio; Miguel Navarro; Agustin Benito; Jean-Mathieu Bart
Journal:  Front Microbiol       Date:  2015-07-24       Impact factor: 5.640

10.  Expression of Trypanosoma brucei gambiense Antigens in Leishmania tarentolae. Potential for Use in Rapid Serodiagnostic Tests (RDTs).

Authors:  Barrie Rooney; Turid Piening; Philippe Büscher; Stijn Rogé; C Mark Smales
Journal:  PLoS Negl Trop Dis       Date:  2015-12-09
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