Literature DB >> 24709260

Luliconazole demonstrates potent in vitro activity against dermatophytes recovered from patients with onychomycosis.

Nathan P Wiederhold1, Annette W Fothergill1, Dora I McCarthy1, Amir Tavakkol2.   

Abstract

The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared to 0.0194 to 0.3107 μg/ml for the three other agents. The in vitro potency of luliconazole was maintained regardless of the dermatophyte species.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24709260      PMCID： PMC4068440          DOI： 10.1128/AAC.02706-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

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