| Literature DB >> 2470904 |
P C Unangst1, D T Connor, S R Stabler, R J Weikert, M E Carethers, J A Kennedy, D O Thueson, J C Chestnut, R L Adolphson, M C Conroy.
Abstract
The synthesis and antiallergic potential of a series of novel indolecarboxamidotetrazoles are described. A number of compounds inhibit the release of histamine from anti-IgE-stimulated basophilic leukocytes obtained from allergic donors. Optimal inhibition is exhibited by compounds with 3-alkoxy, 5-methoxy, and 1-phenyl substituents on the indole core structure. Compound 8d (5-methoxy-3-(1-methylethoxy)-1-phenyl-N-1H-tetrazol-5-yl-1H -indole-2-carboxamide; designated CI-949) is a potent inhibitor of histamine release from human basophils and from guinea pig and human chopped lung.Entities:
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Year: 1989 PMID： 2470904 DOI： 10.1021/jm00126a036
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446