AIM: To evaluate the safety and diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in a cohort of pancreatic cancer patients. METHODS: Of 213 patients with pancreatic cancer evaluated between April 2007 and August 2011, 82 were thought to have resectable pancreatic cancer on the basis of cross-sectional imaging findings. Of these, 54 underwent EUS-FNA before surgery (FNA+ group) and 28 underwent surgery without preoperative EUS-FNA (FNA- group). RESULTS: All 54 lesions were visible on EUS, and all 54 attempts at FNA were technically successful. The diagnostic accuracy according to cytology and histology findings was 98.1% (53/54) and 77.8% (42/54), respectively, and the total accuracy was 98.1% (53/54). One patient developed mild pancreatitis after EUS-FNA but was successfully treated by conservative therapy. No severe complications occurred after EUS-FNA. In the FNA+ and FNA- groups, the median relapse-free survival (RFS) was 742 and 265 d, respectively (P = 0.0099), and the median overall survival (OS) was 1042 and 557 d, respectively (P = 0.0071). RFS and OS were therefore not inferior in the FNA+ group. These data indicate that the use of EUS-FNA did not influence RFS or OS, nor did it increase the risk of peritoneal recurrence. CONCLUSION: In patients with resectable pancreatic cancer, preoperative EUS-FNA is a safe and accurate diagnostic method.
AIM: To evaluate the safety and diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in a cohort of pancreatic cancerpatients. METHODS: Of 213 patients with pancreatic cancer evaluated between April 2007 and August 2011, 82 were thought to have resectable pancreatic cancer on the basis of cross-sectional imaging findings. Of these, 54 underwent EUS-FNA before surgery (FNA+ group) and 28 underwent surgery without preoperative EUS-FNA (FNA- group). RESULTS: All 54 lesions were visible on EUS, and all 54 attempts at FNA were technically successful. The diagnostic accuracy according to cytology and histology findings was 98.1% (53/54) and 77.8% (42/54), respectively, and the total accuracy was 98.1% (53/54). One patient developed mild pancreatitis after EUS-FNA but was successfully treated by conservative therapy. No severe complications occurred after EUS-FNA. In the FNA+ and FNA- groups, the median relapse-free survival (RFS) was 742 and 265 d, respectively (P = 0.0099), and the median overall survival (OS) was 1042 and 557 d, respectively (P = 0.0071). RFS and OS were therefore not inferior in the FNA+ group. These data indicate that the use of EUS-FNA did not influence RFS or OS, nor did it increase the risk of peritoneal recurrence. CONCLUSION: In patients with resectable pancreatic cancer, preoperative EUS-FNA is a safe and accurate diagnostic method.
Authors: Janak N Shah; Douglas Fraker; DuPont Guerry; Michael Feldman; Michael L Kochman Journal: Gastrointest Endosc Date: 2004-06 Impact factor: 9.427
Authors: P B Cotton; G Lehman; J Vennes; J E Geenen; R C Russell; W C Meyers; C Liguory; N Nickl Journal: Gastrointest Endosc Date: 1991 May-Jun Impact factor: 9.427
Authors: T M van Gulik; J W Reeders; A Bosma; T M Moojen; N J Smits; J H Allema; E A Rauws; G J Offerhaus; H Obertop; D J Gouma Journal: Gastrointest Endosc Date: 1997-11 Impact factor: 9.427
Authors: Mohamad A Eloubeidi; Frank G Gress; Thomas J Savides; Maurits J Wiersema; Michael L Kochman; Nuzhat A Ahmad; Gregory G Ginsberg; Richard A Erickson; John Dewitt; Jacques Van Dam; Nicholas J Nickl; Michael J Levy; Jonathan E Clain; Amitabh Chak; Michael V Sivak; Richard Wong; Gerard Isenberg; James M Scheiman; Brenna Bounds; Michael B Kimmey; Michael D Saunders; Kenneth J Chang; Ashish Sharma; Phoniex Nguyen; John G Lee; Steven A Edmundowicz; Dayna Early; Riad Azar; Babak Etemad; Yang K Chen; Irving Waxman; Vanessa Shami; Mark F Catalano; C Mel Wilcox Journal: Gastrointest Endosc Date: 2004-09 Impact factor: 9.427
Authors: Mona M Mamdouh; Hussein Okasha; Hebat Allah M Shaaban; Nesreen H Hafez; Emad Hamza El-Gemeie Journal: Asian Pac J Cancer Prev Date: 2021-10-01
Authors: Asif Ali; Victoria Brown; Simon Denley; Nigel B Jamieson; Jennifer P Morton; Colin Nixon; Janet S Graham; Owen J Sansom; C Ross Carter; Colin J McKay; Fraser R Duthie; Karin A Oien Journal: BMC Clin Pathol Date: 2014-07-23