| Literature DB >> 24707 |
N Pilpel, S O Otuyemi, T R Kurup.
Abstract
A study has been made of the effects produced on the disintegration and dissolution times of chloroquine phosphate tablets by varying their moisture and starch contents and the distribution of the starch in the formulation. 3 to 5% w/w of moisture produces a maximum in the disintegration and dissolution times. Starch added externally as a powder acts only as a disintegrating agent for the tablets, but starch added internally as a paste during granulation acts both as a binding agent and a disintegrant.Entities:
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Year: 1978 PMID： 24707 DOI： 10.1111/j.2042-7158.1978.tb13207.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765