Jonathan Wong1, Prakesh S Shah2, Eugene W Yoon3, Wendy Yee4, Shoo Lee2, Kimberly Dow1. 1. Department of Pediatrics, Kingston General Hospital, Kingston, Ontario, Canada. 2. Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada. 3. MiCare Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada. 4. Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada.
Abstract
OBJECTIVE: To compare neonatal outcomes between infants who received inotropes and those who did not, and identify variation in inotrope use. STUDY DESIGN: Retrospective review of data from neonates < 29 weeks gestation collected by the Canadian Neonatal Network during 2003 to 2010. After controlling for confounders and maternal/infant characteristics, rates of mortality and major morbidity were compared between those who received inotropes on days 1 and 3 of admission and those who did not. Rate of inotrope use was compared between sites. RESULTS: Inotropes were administered to 772 (10%) of the 7,913 neonates. Infants who received inotropes had significantly higher illness severity, surfactant use, and need for mechanical ventilation. Inotrope use was also associated with significantly higher rates of mortality (adjusted odds ratio [AOR] = 2.05 [1.64, 2.57]), retinopathy of prematurity (AOR = 2.04 [1.54, 2.71]), intraventricular hemorrhage (AOR = 1.59 [1.29, 1.93]), bronchopulmonary dysplasia (AOR = 1.38 [1.11, 1.72]), and necrotizing enterocolitis (AOR = 2.06 [1.59, 2.67]). Rates of inotrope use varied significantly between participating sites (0-36%; AOR = 0 [0, 0.1]-7.7 [2.9, 21]). CONCLUSION: Risk of mortality and major morbidities were significantly higher in neonates who received inotropes. Inotrope use varied significantly among Canadian neonatal intensive care units. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
OBJECTIVE: To compare neonatal outcomes between infants who received inotropes and those who did not, and identify variation in inotrope use. STUDY DESIGN: Retrospective review of data from neonates < 29 weeks gestation collected by the Canadian Neonatal Network during 2003 to 2010. After controlling for confounders and maternal/infant characteristics, rates of mortality and major morbidity were compared between those who received inotropes on days 1 and 3 of admission and those who did not. Rate of inotrope use was compared between sites. RESULTS: Inotropes were administered to 772 (10%) of the 7,913 neonates. Infants who received inotropes had significantly higher illness severity, surfactant use, and need for mechanical ventilation. Inotrope use was also associated with significantly higher rates of mortality (adjusted odds ratio [AOR] = 2.05 [1.64, 2.57]), retinopathy of prematurity (AOR = 2.04 [1.54, 2.71]), intraventricular hemorrhage (AOR = 1.59 [1.29, 1.93]), bronchopulmonary dysplasia (AOR = 1.38 [1.11, 1.72]), and necrotizing enterocolitis (AOR = 2.06 [1.59, 2.67]). Rates of inotrope use varied significantly between participating sites (0-36%; AOR = 0 [0, 0.1]-7.7 [2.9, 21]). CONCLUSION: Risk of mortality and major morbidities were significantly higher in neonates who received inotropes. Inotrope use varied significantly among Canadian neonatal intensive care units. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Authors: Ningxin Luo; Siyuan Jiang; Patrick J McNamara; Xiaoying Li; Yan Guo; Yang Wang; Junyan Han; Yingping Deng; Yi Yang; Shoo K Lee; Yun Cao Journal: Front Pediatr Date: 2021-04-22 Impact factor: 3.418
Authors: Laura E Miller; Matthew M Laughon; Reese H Clark; Kanecia O Zimmerman; Christoph P Hornik; Samia Aleem; P Brian Smith; Rachel G Greenberg Journal: J Perinatol Date: 2021-03-23 Impact factor: 3.225
Authors: Emily A Partridge; Marcus G Davey; Matthew A Hornick; Patrick E McGovern; Ali Y Mejaddam; Jesse D Vrecenak; Carmen Mesas-Burgos; Aliza Olive; Robert C Caskey; Theodore R Weiland; Jiancheng Han; Alexander J Schupper; James T Connelly; Kevin C Dysart; Jack Rychik; Holly L Hedrick; William H Peranteau; Alan W Flake Journal: Nat Commun Date: 2017-04-25 Impact factor: 14.919
Authors: Thillagavathie Pillay; Neena Modi; Oliver Rivero-Arias; Brad Manktelow; Sarah E Seaton; Natalie Armstrong; Elizabeth S Draper; Kelvin Dawson; Alexis Paton; Abdul Qader Tahir Ismail; Miaoqing Yang; Elaine M Boyle Journal: BMJ Open Date: 2019-08-22 Impact factor: 2.692