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Literature DB >> 24704795

Drosophila melanogaster as a genetic model system to study neurotransmitter transporters.

Abstract

The model genetic organism Drosophila melanogaster, commonly known as the fruit fly, uses many of the same neurotransmitters as mammals and very similar mechanisms of neurotransmitter storage, release and recycling. This system offers a variety of powerful molecular-genetic methods for the study of transporters, many of which would be difficult in mammalian models. We review here progress made using Drosophila to understand the function and regulation of neurotransmitter transporters and discuss future directions for its use.

Entities: Gene Species

Keywords: Acetylcholine; ChT1; DAT; Dopamine; Drosophila; EAAT; GABA; GAT; Glutamate; Inebriated; Neurotransmitter transporter; Octopamine; Portabella; SERT; SLC1; SLC17; SLC18; SLC6; Serotonin; VAChT; VGAT; VGLUT; VMAT; VNUT; Vesicular transporter

Mesh：

Substances：

Year: 2014 PMID： 24704795 PMCID： PMC4264877 DOI： 10.1016/j.neuint.2014.03.015

Source DB: PubMed Journal: Neurochem Int ISSN： 0197-0186 Impact factor: 3.921

274 in total

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Review 2. New insights into the mechanism of action of amphetamines.

Authors: Annette E Fleckenstein; Trent J Volz; Evan L Riddle; James W Gibb; Glen R Hanson
Journal: Annu Rev Pharmacol Toxicol Date: 2007 Impact factor: 13.820

3. Sorting of the vesicular GABA transporter to functional vesicle pools by an atypical dileucine-like motif.

Authors: Magda S Santos; C Kevin Park; Sarah M Foss; Haiyan Li; Susan M Voglmaier
Journal: J Neurosci Date: 2013-06-26 Impact factor: 6.167

4. Overexpression of the Drosophila vesicular monoamine transporter increases motor activity and courtship but decreases the behavioral response to cocaine.

Authors: H-Y Chang; A Grygoruk; E S Brooks; L C Ackerson; N T Maidment; R J Bainton; D E Krantz
Journal: Mol Psychiatry Date: 2006-01 Impact factor: 15.992

5. Differential ultrastructure of synaptic terminals on ventral longitudinal abdominal muscles in Drosophila larvae.

Authors: H L Atwood; C K Govind; C F Wu
Journal: J Neurobiol Date: 1993-08

6. Functionally distinct dopamine and octopamine transporters in the CNS of the cabbage looper moth.

Authors: Pamela Gallant; Tabita Malutan; Heather McLean; LouAnn Verellen; Stanley Caveney; Cam Donly
Journal: Eur J Biochem Date: 2003-02

7. Two functional but noncomplementing Drosophila tyrosine decarboxylase genes: distinct roles for neural tyramine and octopamine in female fertility.

Authors: Shannon H Cole; Ginger E Carney; Colleen A McClung; Stacey S Willard; Barbara J Taylor; Jay Hirsh
Journal: J Biol Chem Date: 2005-02-03 Impact factor: 5.157

Review 8. Physiological roles of taurine in heart and muscle.

Authors: Stephen W Schaffer; Chian Ju Jong; K C Ramila; Junichi Azuma
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9. Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites.

Authors: Robert T Fremeau; Kaiwen Kam; Tayyaba Qureshi; Juliette Johnson; David R Copenhagen; Jon Storm-Mathisen; Farrukh A Chaudhry; Roger A Nicoll; Robert H Edwards
Journal: Science Date: 2004-04-29 Impact factor: 47.728

10. Functional comparison of full-length and N-terminal-truncated octopamine transporters from Lepidoptera.

Authors: Cam Donly; LouAnn Verellen; Wendy Cladman; Stan Caveney
Journal: Insect Biochem Mol Biol Date: 2007-05-03 Impact factor: 4.714

37 in total

Review 1. Vesicular nucleotide transporter (VNUT): appearance of an actress on the stage of purinergic signaling.

Authors: Yoshinori Moriyama; Miki Hiasa; Shohei Sakamoto; Hiroshi Omote; Masatoshi Nomura
Journal: Purinergic Signal Date: 2017-06-14 Impact factor: 3.765

2. Differential maturation of vesicular glutamate and GABA transporter expression in the mouse auditory forebrain during the first weeks of hearing.

Authors: Troy A Hackett; Amanda R Clause; Toru Takahata; Nicholas J Hackett; Daniel B Polley
Journal: Brain Struct Funct Date: 2015-07-10 Impact factor: 3.270

3. Stratification of astrocytes in healthy and diseased brain.

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Journal: Brain Pathol Date: 2017-09 Impact factor: 6.508

4. An infection of Enterobacter ludwigii affects development and causes age-dependent neurodegeneration in Drosophila melanogaster.

Authors: Subhashree Priyadarsini; Moumita Sahoo; Swetapadma Sahu; Rasu Jayabalan; Monalisa Mishra
Journal: Invert Neurosci Date: 2019-10-22

5. Comparison of dopamine kinetics in the larval Drosophila ventral nerve cord and protocerebrum with improved optogenetic stimulation.

Authors: Eve Privman; B Jill Venton
Journal: J Neurochem Date: 2015-09-18 Impact factor: 5.372

10. Positional stable isotope tracer analysis reveals carbon routes during ammonia metabolism of Aedes aegypti mosquitoes.

Authors: Thomas D Horvath; Shai Dagan; Philip L Lorenzi; David H Hawke; Patricia Y Scaraffia
Journal: FASEB J Date: 2017-09-25 Impact factor: 5.191