| Literature DB >> 24704686 |
Yi Zhang1, Dayong Zheng2, Yan Xiong1, Chengbiao Xue1, Gen Chen1, Bibo Yan1, Qifa Ye3.
Abstract
MicroRNAs have emerged as important regulators of carcinogenesis. In the current study, we observed that microRNA-202 (miR-202) is downregulated in hepatocellular carcinoma (HCC) cells and tissues, indicating a significant correlation between miR-202 expression and HCC progression. Overexpression of miR-202 in HCC cells suppressed cell proliferation and tumorigenicity, while downregulation of miR-202 enhanced the cells' proliferative capacity. Furthermore, we identified low-density lipoprotein receptor-related protein 6 (LRP6) as a direct target of miR-202. miR-202 suppresses the expression of LRP6 by binding to the 3'-untranslated region (UTR) of its mRNA. Finally, we found that silencing the expression of LRP6 is the essential biological function of miR-202 during HCC cell proliferation. Collectively, our findings reveal that miR-202 is a potential tumor suppressive miRNA that participates in carcinogenesis of human HCC by suppressing LRP6 expression.Entities:
Keywords: Hepatocellular carcinoma; Proliferation; lipoprotein receptor-related protein 6; microRNA-202
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Year: 2014 PMID： 24704686 DOI： 10.1016/j.febslet.2014.03.030
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124