| Literature DB >> 24704578 |
Margarida Saramago1, Cátia Bárria1, Ricardo F Dos Santos1, Inês J Silva1, Vânia Pobre1, Susana Domingues1, José M Andrade1, Sandra C Viegas1, Cecília M Arraiano2.
Abstract
Ribonucleases (RNases) are key factors in the control of biological processes, since they modulate the processing, degradation and quality control of RNAs. This review gives many illustrative examples of the role of RNases in the regulation of small RNAs (sRNAs). RNase E and PNPase have been shown to degrade the free pool of sRNAs. RNase E can also be recruited to cleave mRNAs when they are interacting with sRNAs. RNase III cleaves double-stranded structures, and can cut both the sRNA and its RNA target when they are hybridized. Overall, ribonucleases act as conductors in the control of sRNAs. Therefore, it is very important to further understand their role in the post-transcriptional control of gene expression.Entities:
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Year: 2014 PMID： 24704578 DOI： 10.1016/j.mib.2014.02.009
Source DB: PubMed Journal: Curr Opin Microbiol ISSN： 1369-5274 Impact factor: 7.934