| Literature DB >> 24704506 |
Murat Cokol1, Zohar B Weinstein2, Kaan Yilancioglu2, Murat Tasan3, Allison Doak4, Dilay Cansever2, Beste Mutlu2, Siyang Li3, Raul Rodriguez-Esteban5, Murodzhon Akhmedov6, Aysegul Guvenek6, Melike Cokol6, Selim Cetiner6, Guri Giaever7, Ivan Iossifov8, Corey Nislow7, Brian Shoichet4, Frederick P Roth9.
Abstract
One drug may suppress the effects of another. Although knowledge of drug suppression is vital to avoid efficacy-reducing drug interactions or discover countermeasures for chemical toxins, drug-drug suppression relationships have not been systematically mapped. Here, we analyze the growth response of Saccharomyces cerevisiae to anti-fungal compound ("drug") pairs. Among 440 ordered drug pairs, we identified 94 suppressive drug interactions. Using only pairs not selected on the basis of their suppression behavior, we provide an estimate of the prevalence of suppressive interactions between anti-fungal compounds as 17%. Analysis of the drug suppression network suggested that Bromopyruvate is a frequently suppressive drug and Staurosporine is a frequently suppressed drug. We investigated potential explanations for suppressive drug interactions, including chemogenomic analysis, coaggregation, and pH effects, allowing us to explain the interaction tendencies of Bromopyruvate.Entities:
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Year: 2014 PMID： 24704506 PMCID： PMC4281482 DOI： 10.1016/j.chembiol.2014.02.012
Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521