Li-Xia Sun1, Jing Zhang2. 1. Department of Cardiology, Fifth People's Hospital of Dalian, Liaoning, China. 2. Department of Cardiology, Fifth People's Hospital of Dalian, Liaoning, China. Electronic address: zhangjing201309@126.com.
Abstract
BACKGROUND: Everolimus-eluting stents are associated with low risk of stent thrombosis and stent restenosis, and the new generation of stents with biodegradable polymer were designed to reduce that risk. However, the benefits have been variable. METHODS AND RESULTS: Four RCTs with a total of 8282 patients were included. Overall, BP-DES was not inferior to EES with equivalent risk of TVR (relative risk [RR], 1.07; 95% confidence interval [CI], 0.91-1.27; P=0.414; I(2)=0.0%) and ARC definite and/or probable ST (RR, 1.06; 95% CI, 0.66-1.70; P=0.810; I(2)=4.8%). Furthermore, there was no difference in all-cause mortality (RR, 1.06; 95% CI, 0.84-1.33; P=0.651; I(2)=0.0%), myocardial infarction (RR, 1.12; 95% CI, 0.88-1.44; P=0.360; I(2)=0.0%), and MACE (RR, 1.00; 95% CI, 0.87-1.15; P=0.975; I(2)=0.0%) between the two groups. CONCLUSIONS: The new generation of biodegradable polymer stents were not inferior to EES for equivalent risk of MACE and ST.
BACKGROUND:Everolimus-eluting stents are associated with low risk of stent thrombosis and stent restenosis, and the new generation of stents with biodegradable polymer were designed to reduce that risk. However, the benefits have been variable. METHODS AND RESULTS: Four RCTs with a total of 8282 patients were included. Overall, BP-DES was not inferior to EES with equivalent risk of TVR (relative risk [RR], 1.07; 95% confidence interval [CI], 0.91-1.27; P=0.414; I(2)=0.0%) and ARC definite and/or probable ST (RR, 1.06; 95% CI, 0.66-1.70; P=0.810; I(2)=4.8%). Furthermore, there was no difference in all-cause mortality (RR, 1.06; 95% CI, 0.84-1.33; P=0.651; I(2)=0.0%), myocardial infarction (RR, 1.12; 95% CI, 0.88-1.44; P=0.360; I(2)=0.0%), and MACE (RR, 1.00; 95% CI, 0.87-1.15; P=0.975; I(2)=0.0%) between the two groups. CONCLUSIONS: The new generation of biodegradable polymer stents were not inferior to EES for equivalent risk of MACE and ST.
Authors: Abhilash Akinapelli; Jack P Chen; Kristine Roy; Joseph Donnelly; Keith Dawkins; Barbara Huibregtse; Dongming Hou Journal: Curr Cardiol Rev Date: 2017