Literature DB >> 24704429

Piecemeal necrosis of the liver revisited a review.

S W French1, E T Enbom2.   

Abstract

Piecemeal necrosis of the liver is thought to lead to liver cell necrosis. However the process does not lead to necrosis but rather lead to gradual progressive piecemeal removal of liver cell cytoplasm by T lymphocytes which are sensitized to antigens presented on the liver cell surface to form the immunologic synapse. The cytoplasm is taken up by the T cell and digested by the lysosome in the lymphocyte. By this mechanism the liver cell gradually disappears like the Cheshire cat in Alice in Wonderland.
Copyright © 2014. Published by Elsevier Inc.

Entities:  

Keywords:  Autoimmunity; Immunologic synapse; Necrosis

Mesh：

Year:  2014        PMID： 24704429     DOI： 10.1016/j.yexmp.2014.03.009

Source DB:  PubMed          Journal:  Exp Mol Pathol        ISSN： 0014-4800            Impact factor:   3.362


  2 in total

1.  Troxis necrosis, a novel mechanism for drug-induced hepatitis secondary to immunomodulatory therapy.

Authors:  Christina H Wei; Andrew Penunuri; George Karpouzas; Wayne Fleishman; Anuj Datta; Samuel W French
Journal:  Exp Mol Pathol       Date:  2015-08-20       Impact factor: 3.362

2.  Influence of hepatic fibrosis and inflammation: Correlation between histopathological changes and Gd-EOB-DTPA-enhanced MR imaging.

Authors:  N Verloh; U Probst; K Utpatel; F Zeman; F Brennfleck; J M Werner; C Fellner; C Stroszczynski; M Evert; P Wiggermann; M Haimerl
Journal:  PLoS One       Date:  2019-05-13       Impact factor: 3.240
  2 in total

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