Literature DB >> 24704416

Bone defects: molecular and cellular therapeutic targets.

Vincenzo Desiderio1, Virginia Tirino2, Gianpaolo Papaccio3, Francesca Paino1.   

Abstract

Bone defects are one of the most serious pathologies that need tissue regeneration therapies. Studies on mesenchymal stem cells are changing the way we treat bone diseases. MSCs have been used for the treatment of osteogenesis imperfecta, hypophosphatasia, osteonecrosis of the femoral head, osteoporosis, rheumatoid arthritis and osteoarthritis. In this context, it is becoming ever more clear that the future of therapies will be based on the use of stem cells. In this concise review, we highlight the importance of the use of MSCs in bone diseases, focusing on the role of histone deacetylases and Wnt pathways involved in osteogenesis. A better understanding of MSC biology and osteogenesis is needed in order to develop new and targeted therapeutic strategies for the treatment of bone diseases/disorders.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Bone disease; Histone deacetylases; Mesenchymal stem cells; Wnt pathway

Mesh：

Substances：

Year:  2014        PMID： 24704416     DOI： 10.1016/j.biocel.2014.03.025

Source DB:  PubMed          Journal:  Int J Biochem Cell Biol        ISSN： 1357-2725            Impact factor:   5.085


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