| Literature DB >> 24704293 |
Sheng-Xian Yuan1, Qi-Fei Tao2, Jie Wang3, Fu Yang4, Lei Liu5, Li-Li Wang6, Jin Zhang7, Yuan Yang8, Hui Liu9, Fang Wang10, Shu-Han Sun11, Wei-Ping Zhou12.
Abstract
About 61-72% of transcribed regions possess long noncoding RNAs in antisense orientation (Antisense long noncoding RNAs, aslncRNAs). However, the function of aslncRNAs in HCC remains unclear. We found numerous aslncRNAs were deregulated and might be involved in regulatory gene-net of HCC. The PCNA-AS1, antisense to PCNA, is significantly up-regulated in HCC and could promote tumor growth in vitro and in vivo. The effects of PCNA-AS1 rely on regulation of PCNA via forming RNA hybridization to increase PCNA mRNA stability. We concluded that aslncRNAs might act as upstream regulators in HCC and PCNA-AS1 could serve as a novel therapeutic target.Entities:
Keywords: Antisense RNA; Long noncoding RNA; RNA hybridazation; RNA stability; Tumor growth
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Year: 2014 PMID： 24704293 DOI： 10.1016/j.canlet.2014.03.029
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679