Literature DB >> 2470418

Ionic pores formed by cyclic peptides.

F Heitz1, F Kaddari, N Van Mau, J Verducci, H Raniri Seheno, R Lazaro.   

Abstract

It is shown that 2 cyclic tetrapeptides, namely tentoxin and HC toxin, are able to induce the formation of transmembrane ionic channels, although a carrier mechanism could be expected on the basis of their chemical structure (presence of proline or N-methylated residues). Since other cyclic peptides but of larger size, i.e., tyrocidines, gramicidin S (decapeptides) and an octapeptide with a sequence similar to that of HC toxin, are also able to form pores, it appears that this property can be extended to a large number of cyclic peptides. A pore structure based on aggregates is proposed.

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Year:  1989        PMID: 2470418     DOI: 10.1016/0300-9084(89)90134-x

Source DB:  PubMed          Journal:  Biochimie        ISSN: 0300-9084            Impact factor:   4.079


  5 in total

1.  Interaction of gramicidin S and its aromatic amino-acid analog with phospholipid membranes.

Authors:  Masoud Jelokhani-Niaraki; Robert S Hodges; Joseph E Meissner; Una E Hassenstein; Laura Wheaton
Journal:  Biophys J       Date:  2008-07-11       Impact factor: 4.033

2.  The antimicrobial peptide gramicidin S permeabilizes phospholipid bilayer membranes without forming discrete ion channels.

Authors:  Md Ashrafuzzaman; O S Andersen; R N McElhaney
Journal:  Biochim Biophys Acta       Date:  2008-09-05

3.  Diastereoisomeric analogues of gramicidin S: structure, biologicalactivity and interaction with lipid bilayers.

Authors:  M Jelokhani-Niaraki; L H Kondejewski; S W Farmer; R E Hancock; C M Kay; R S Hodges
Journal:  Biochem J       Date:  2000-08-01       Impact factor: 3.857

4.  Direct evidence of plant-pathogenic activity of fungal metabolites of Trichothecium roseum on apple.

Authors:  Martin Zabka; Kamila Drastichová; Alexandr Jegorov; Julie Soukupová; Ladislav Nedbal
Journal:  Mycopathologia       Date:  2006-07       Impact factor: 2.574

Review 5.  Modification of membrane permeability by animal viruses.

Authors:  L Carrasco
Journal:  Adv Virus Res       Date:  1995       Impact factor: 9.937

  5 in total

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