| Literature DB >> 2470418 |
F Heitz1, F Kaddari, N Van Mau, J Verducci, H Raniri Seheno, R Lazaro.
Abstract
It is shown that 2 cyclic tetrapeptides, namely tentoxin and HC toxin, are able to induce the formation of transmembrane ionic channels, although a carrier mechanism could be expected on the basis of their chemical structure (presence of proline or N-methylated residues). Since other cyclic peptides but of larger size, i.e., tyrocidines, gramicidin S (decapeptides) and an octapeptide with a sequence similar to that of HC toxin, are also able to form pores, it appears that this property can be extended to a large number of cyclic peptides. A pore structure based on aggregates is proposed.Entities:
Mesh:
Substances:
Year: 1989 PMID: 2470418 DOI: 10.1016/0300-9084(89)90134-x
Source DB: PubMed Journal: Biochimie ISSN: 0300-9084 Impact factor: 4.079