| Literature DB >> 24704028 |
Kouki Matsuda1, Shinichiro Hattori1, Yuji Komizu2, Ryusho Kariya1, Ryuichi Ueoka2, Seiji Okada3.
Abstract
The anti-HIV-1 activity of cepharanthine (CEP), a natural product derived from Stephania cepharantha Hayata, was evaluated. CEP stabilized plasma membrane fluidity and inhibited HIV-1 envelope-dependent cell-to-cell fusion of HIV-1-infected cells as well as cell-free infection. It is suggested that CEP inhibited the HIV-1 entry process by reducing plasma membrane fluidity, and the plasma membrane is therefore an identical target to prevent viral infection.Entities:
Keywords: Cell fusion; Cepharanthine; HIV-1; Membrane fluidity; Viral infection
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Year: 2014 PMID： 24704028 DOI： 10.1016/j.bmcl.2014.03.041
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823