| Literature DB >> 24703892 |
Paloma Martín Martorell1, Marisol Huerta Alvaro2, Miguel A Solís Salguero3, Amelia Insa Molla2.
Abstract
A 69 year old man with idiopathic chronic kidney disease was diagnosed with relapsing EGFR negative, ALK positive lung adenocarcinoma, and treated with chemotherapy and antiangiogenic treatment, under which his renal insufficiency worsened. During second line crizotinib treatment, further worsening of the renal function was seen, with very clear correlation with crizotinib withdrawal and rechallenge. No further drug causes for the worsening blood creatinine values were detected.Entities:
Keywords: ALK; Crizotinib; Lung adenocarcinoma; Renal insufficiency; Toxicity; Tyrosine kinase inhibitors
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Year: 2014 PMID: 24703892 DOI: 10.1016/j.lungcan.2014.03.001
Source DB: PubMed Journal: Lung Cancer ISSN: 0169-5002 Impact factor: 5.705