Hypomelanosis of Ito: neurologic complications.

Hypomelanosis of Ito is an uncommon, but clinically recognizable neurocutaneous syndrome. Neurologic complications are frequent and most commonly include seizures, psychomotor delays, changes in tone, and gait disturbances. Four patients with hypomelanosis of Ito and neurologic complications are presented; one patient had an associated chromosome aberration not reported previously.