Literature DB >> 2470373

cDNA coding for the entire human prostate specific antigen shows high homologies to the human tissue kallikrein genes.

P Henttu1, P Vihko.   

Abstract

We have isolated four cDNAs encoding the entire preproprotein of prostate specific antigen from human prostatic cDNA libraries. Comparison of the coding regions of prostate specific antigen with human pancreatic kallikrein (1-3) and human glandular kallikrein (4) showed 73%-84% nucleotide and 61-77% amino acid homologies, respectively, between these enzymes. Also the 3' noncoding regions of these genes were conserved. The close resemblance of prostate specific antigen, a marker for prostatic cancer, to glandular kallikrein suggests related immunogenic properties for them.

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Year:  1989        PMID： 2470373     DOI： 10.1016/0006-291x(89)92520-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

1.  Crystallization and preliminary crystallographic studies of human kallikrein 7, a serine protease of the multigene kallikrein family.

Authors:  Israel S Fernández; Ludger Ständker; Wolf Georg Forssmann; Guillermo Giménez-Gallego; Antonio Romero
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2007-07-07

2.  A novel protease homolog differentially expressed in breast and ovarian cancer.

Authors:  A Anisowicz; G Sotiropoulou; G Stenman; S C Mok; R Sager
Journal:  Mol Med       Date:  1996-09       Impact factor: 6.354

3.  Enhancement of antitumour immunity by a novel chemotactic antigen DNA vaccine encoding chemokines and multiepitopes of prostate-tumour-associated antigens.

Authors:  Hanjun Qin; Chunxia Zhou; Dongmei Wang; Wenbo Ma; Xiao Liang; Chen Lin; Youhui Zhang; Shuren Zhang
Journal:  Immunology       Date:  2006-03       Impact factor: 7.397

4.  Steroid hormone regulation of prostate-specific antigen gene expression in breast cancer.

Authors:  N Zarghami; L Grass; E P Diamandis
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

5.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1989-09-25       Impact factor: 16.971
  5 in total

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