| Literature DB >> 2470353 |
A Beitz1, C Taube, J Beitz, H Goos, J Graff, J Nohring, K F Lindenau, H J Mest.
Abstract
The effect of drugs on eicosanoid production and on the development of atherogenic index was investigated in canine myocardial ischemia. Iloprost, verapamil, the trapidil derivative AR 12463 or 0.9% NaCl solution were administered 60 min after coronary artery ligation in anaesthetized dogs. Both iloprost and AR 12463 reduced the thromboxane A2/prostacyclin (TXA2/PGI2) ratio in coronary sinus plasma in comparison to controls. The atherogenic index was significantly decreased in the iloprost as well as in the AR 12463-treated group in comparison to the control group. Verapamil had no influence on the investigated parameters.Entities:
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Year: 1988 PMID： 2470353
Source DB: PubMed Journal: Biomed Biochim Acta ISSN： 0232-766X