G Arbane1, A Douiri2, N Hart1, N S Hopkinson3, S Singh4, C Speed5, B Valladares5, R Garrod6. 1. NIHR Biomedical Research Centre, Guy's and St Thomas' Foundation Trust and Kings College London, UK. 2. NIHR Biomedical Research Centre, Guy's and St Thomas' Foundation Trust and Kings College London, UK; Division of Health and Social Care Research, King's College London, UK. 3. NIHR Respiratory Biomedical Research Unit at Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK. 4. Centre for Exercise and Rehabilitation Science, University Hospitals of Leicester NHS Trust, Leicester, UK. 5. King's College London, Denmark Hill Campus, London, UK. 6. King's College London, Denmark Hill Campus, London, UK. Electronic address: rachel.garrod@nhs.net.
Abstract
OBJECTIVE: To evaluate the effect of a combined hospital plus home exercise programme following curative surgery for non-small cell lung cancer (NSCLC). DESIGN: Randomised controlled trial. SETTING: Teaching hospital. PARTICIPANTS: One hundred and thirty-one subjects with NSCLC admitted for curative surgery. INTERVENTIONS: Participants were randomised to usual care or a hospital plus home exercise programme. OUTCOMES: The primary outcome was the between-group difference in physical activity 4 weeks after surgery. Secondary outcomes were the difference in quadriceps strength, exercise tolerance and quality of life [Short Form-36 (SF-36) and European Organisation for Research and Treatment of Cancer (EORTC) QLQ-LC13] from pre-operatively (baseline) to 4 weeks after surgery. RESULTS: The participants (n=131) had a mean age of 68 [standard deviation (SD) 11] years and mean forced expiratory volume in 1 second of 2.4 (SD 1.1)l. There were no significant differences in physical activity between the groups 4 weeks after surgery [mean difference adjusted for baseline 12minutes/day, 95% confidence interval (CI) -20.2 to 44.1]. In addition, there were no significant differences in total SF-36 or EORTC QLQ-LC13 scores from baseline to 4 weeks after surgery. Both groups had recovered their pre-operative walking distance 4 weeks after surgery, and there were no differences between the groups (mean difference in Incremental Shuttle Walk Test from baseline to 4 weeks after surgery (-26m, 95% CI -94.2 to 42.3). CONCLUSIONS: A hospital plus home exercise programme showed little benefit in unselected patients with NSCLC following surgery. Regardless of group allocation, the patients had recovered their pre-operative exercise tolerance levels by 4 weeks after surgery.
RCT Entities:
OBJECTIVE: To evaluate the effect of a combined hospital plus home exercise programme following curative surgery for non-small cell lung cancer (NSCLC). DESIGN: Randomised controlled trial. SETTING: Teaching hospital. PARTICIPANTS: One hundred and thirty-one subjects with NSCLC admitted for curative surgery. INTERVENTIONS:Participants were randomised to usual care or a hospital plus home exercise programme. OUTCOMES: The primary outcome was the between-group difference in physical activity 4 weeks after surgery. Secondary outcomes were the difference in quadriceps strength, exercise tolerance and quality of life [Short Form-36 (SF-36) and European Organisation for Research and Treatment of Cancer (EORTC) QLQ-LC13] from pre-operatively (baseline) to 4 weeks after surgery. RESULTS: The participants (n=131) had a mean age of 68 [standard deviation (SD) 11] years and mean forced expiratory volume in 1 second of 2.4 (SD 1.1)l. There were no significant differences in physical activity between the groups 4 weeks after surgery [mean difference adjusted for baseline 12minutes/day, 95% confidence interval (CI) -20.2 to 44.1]. In addition, there were no significant differences in total SF-36 or EORTC QLQ-LC13 scores from baseline to 4 weeks after surgery. Both groups had recovered their pre-operative walking distance 4 weeks after surgery, and there were no differences between the groups (mean difference in Incremental Shuttle Walk Test from baseline to 4 weeks after surgery (-26m, 95% CI -94.2 to 42.3). CONCLUSIONS: A hospital plus home exercise programme showed little benefit in unselected patients with NSCLC following surgery. Regardless of group allocation, the patients had recovered their pre-operative exercise tolerance levels by 4 weeks after surgery.
Authors: Vinicius Cavalheri; Chris Burtin; Vittoria R Formico; Mika L Nonoyama; Sue Jenkins; Martijn A Spruit; Kylie Hill Journal: Cochrane Database Syst Rev Date: 2019-06-17
Authors: Weijiao Zhou; Katelyn E Webster; Ellen Lavoie Smith; Weiyun Chen; Philip T Veliz; Rishindra M Reddy; Janet L Larson Journal: Support Care Cancer Date: 2022-04-06 Impact factor: 3.603
Authors: Qiuling Shi; Xin Shelley Wang; Ara A Vaporciyan; David C Rice; Keyuri U Popat; Charles S Cleeland Journal: J Pain Symptom Manage Date: 2016-08-10 Impact factor: 3.612
Authors: Caroline Himbert; Nicole Klossner; Adriana M Coletta; Christopher A Barnes; Joachim Wiskemann; Paul C LaStayo; Thomas K Varghese; Cornelia M Ulrich Journal: Crit Rev Oncol Hematol Date: 2020-09-13 Impact factor: 6.312
Authors: Rebecca R Turner; Liz Steed; Helen Quirk; Rosa U Greasley; John M Saxton; Stephanie Jc Taylor; Derek J Rosario; Mohamed A Thaha; Liam Bourke Journal: Cochrane Database Syst Rev Date: 2018-09-19