Christina McCord1, Jing Xu2, Wei Xu3, Xin Qiu3, Nidal Muhanna4, Jonathan Irish4, Iona Leong5, Richard John McComb6, Bayardo Perez-Ordonez7, Grace Bradley8. 1. Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada. Electronic address: Christina.mccord@utoronto.ca. 2. Applied Molecular Profiling Laboratory, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada. 3. Department of Biostatistics, University Health Network, Toronto, Ontario, Canada. 4. Department of Surgical Oncology/Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada. 5. Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada. 6. Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada. 7. Department of Pathology, University Health Network, Toronto, Ontario, Canada. 8. Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada; Ontario Cancer Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Abstract
OBJECTIVE: This study aimed to examine atypical and malignant papillary oral lesions for low- and high-risk human papillomavirus (HPV) infection and to correlate HPV infection with clinical and pathologic features. STUDY DESIGN: Sections of 28 atypical papillary lesions (APLs) and 14 malignant papillary lesions (MPLs) were examined for HPV by in situ hybridization and for p16 and MIB-1 by immunohistochemistry; 24 conventional papillomas were studied for comparison. RESULTS: Low-risk HPV was found in 10 of 66 cases, including 9 APLs and 1 papilloma. All low-risk HPV-positive cases showed suprabasilar MIB-1 staining, and the agreement was statistically significant (P < .0001). Diffuse p16 staining combined with high-risk HPV was not seen in any of the cases. A subset of HPV(-) APLs progressed to carcinoma. CONCLUSIONS: Oral papillary lesions are a heterogeneous group. Low-risk HPV infection is associated with a subset of APLs with a benign clinical course. Potentially malignant APLs and MPLs are not associated with low- or high-risk HPV.
OBJECTIVE: This study aimed to examine atypical and malignant papillary oral lesions for low- and high-risk human papillomavirus (HPV) infection and to correlate HPV infection with clinical and pathologic features. STUDY DESIGN: Sections of 28 atypical papillary lesions (APLs) and 14 malignant papillary lesions (MPLs) were examined for HPV by in situ hybridization and for p16 and MIB-1 by immunohistochemistry; 24 conventional papillomas were studied for comparison. RESULTS: Low-risk HPV was found in 10 of 66 cases, including 9 APLs and 1 papilloma. All low-risk HPV-positive cases showed suprabasilar MIB-1 staining, and the agreement was statistically significant (P < .0001). Diffuse p16 staining combined with high-risk HPV was not seen in any of the cases. A subset of HPV(-) APLs progressed to carcinoma. CONCLUSIONS: Oral papillary lesions are a heterogeneous group. Low-risk HPV infection is associated with a subset of APLs with a benign clinical course. Potentially malignant APLs and MPLs are not associated with low- or high-risk HPV.
Authors: Cornelia Peterson; Rupin N Parikh; Meleha T Ahmad; Ashley A Campbell; Yassine Daoud; Nicholas Mahoney; Sepideh Siadati; Charles G Eberhart Journal: Int J Mol Sci Date: 2022-06-29 Impact factor: 6.208
Authors: Benjamin L Witt; Daniel J Albertson; Margaret G Coppin; Christian F Horrocks; Melissa Post; H Evin Gulbahce Journal: Head Neck Pathol Date: 2014-06-17