Literature DB >> 2470331

The human alpha-1-antitrypsin-related sequence gene: isolation and investigation of its expression.

G D Kelsey1, M Parkar, S Povey.   

Abstract

A genomic sequence approximately 5 kb in length designated the alpha-1-antitrypsin-related gene (ATR), showing considerable homology to the human alpha-1-antitrypsin (AAT) gene, was identified 10 kb downstream of the authentic AAT gene. The AAT and ATR genes were introduced separately into L-cells by transfection in order to establish a method for distinguishing between expression of the two genes. RNA probes from the cloned ATR region were then used in a ribonuclease protection assay against RNA from a range of human adult and fetal tissues. No evidence of expression of ATR was found, indicating that this region is probably a pseudogene.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2470331     DOI： 10.1111/j.1469-1809.1988.tb01091.x

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN： 0003-4800            Impact factor:   1.670


  6 in total

1.  Genetic studies on a new deficiency gene (PI*Ztun) at the PI locus.

Authors:  D B Whitehouse; C M Abbott; J U Lovegrove; I McIntosh; C J McMahon; G Mieli-Vergani; A P Mowat; D A Hopkinson
Journal:  J Med Genet       Date:  1989-12       Impact factor: 6.318

2.  Differential regulation of gene activity and chromatin structure within the human serpin gene cluster at 14q32.1 in macrophage microcell hybrids.

Authors:  P Rollini; R E Fournier
Journal:  Nucleic Acids Res       Date:  2000-04-15       Impact factor: 16.971

3.  Molecular linkage of the human alpha 1-antitrypsin and corticosteroid-binding globulin genes on chromosome 14q32.1.

Authors:  P Rollini; R E Fournier
Journal:  Mamm Genome       Date:  1997-12       Impact factor: 2.957

4.  Stable expression and cell-specific chromatin structure of human alpha1-antitrypsin cosmid transgenes in rat hepatoma cells.

Authors:  P Rollini; L Xu; R E Fournier
Journal:  Nucleic Acids Res       Date:  2000-09-15       Impact factor: 16.971

5.  The equine major plasma serpin multigene family: partial characterization including sequence of the reactive-site regions.

Authors:  S D Patterson; K Bell; D C Shaw
Journal:  Biochem Genet       Date:  1991-10       Impact factor: 1.890

6.  Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome I4q32.1.

Authors:  G D Billingsley; M A Walter; G L Hammond; D W Cox
Journal:  Am J Hum Genet       Date:  1993-02       Impact factor: 11.025
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.