Y Darouassi1, H Attifi2, M Zalagh2, I Rharrassi3, F Benariba2. 1. Service d'Oto-Rhino-Laryngologie, Hôpital Militaire d'Instruction Mohammed V, avenue des FAR Hay Riad, 10000 Rabat, Morocco. Electronic address: daryou@yahoo.fr. 2. Service d'Oto-Rhino-Laryngologie, Hôpital Militaire d'Instruction Mohammed V, avenue des FAR Hay Riad, 10000 Rabat, Morocco. 3. Service d'Anatomie Pathologique, Hôpital Militaire d'Instruction Mohammed V, avenue des FAR Hay Riad, 10000 Rabat, Morocco.
Abstract
INTRODUCTION: Myxofibrosarcoma of the thyroid is exceptional: a Medline search found a single case report. We report a new case which raised diagnostic and therapeutic problems. OBSERVATION: We report the case of a 74-year-old woman who presented with swelling of the left thyroid lobe and ipsilateral cervical lymphadenopathy. Total thyroidectomy with cervical lymph-node dissection was performed. Histological analysis diagnosed myxofibrosarcoma. Evolution was marked by rapid local recurrence, and chemotherapy based on doxorubicin and ifosfamide was introduced. DISCUSSION/ CONCLUSION: Head and neck myxofibrosarcoma is rare. MRI is essential and should always precede treatment. Diagnosis is histological. There is elevated risk of local recurrence after resection, accompanied by worsening tumor grade, whence the need for accurate diagnosis, appropriate treatment and regular MRI follow-up.
INTRODUCTION:Myxofibrosarcoma of the thyroid is exceptional: a Medline search found a single case report. We report a new case which raised diagnostic and therapeutic problems. OBSERVATION: We report the case of a 74-year-old woman who presented with swelling of the left thyroid lobe and ipsilateral cervical lymphadenopathy. Total thyroidectomy with cervical lymph-node dissection was performed. Histological analysis diagnosed myxofibrosarcoma. Evolution was marked by rapid local recurrence, and chemotherapy based on doxorubicin and ifosfamide was introduced. DISCUSSION/ CONCLUSION: Head and neck myxofibrosarcoma is rare. MRI is essential and should always precede treatment. Diagnosis is histological. There is elevated risk of local recurrence after resection, accompanied by worsening tumor grade, whence the need for accurate diagnosis, appropriate treatment and regular MRI follow-up.
Authors: Lingxin Zhang; Daniel Lubin; John H Sinard; Brendan C Dickson; Cristina R Antonescu; Hao Wu; Roheena Z Panni; Snjezana Dogan; Brian R Untch; Ronald A Ghossein; Bin Xu Journal: Head Neck Pathol Date: 2022-02-26
Authors: Maria Chara Stylianidi; Lena Haeberle; Matthias Schott; Yuriko Mori; Christina Antke; Frederick Lars Giesel; Gerald Antoch; Irene Esposito; Wolfram Trudo Knoefel; Andreas Krieg Journal: Surg Case Rep Date: 2022-07-25