Yang Xiong1, Xuxue Zhang, Tao Huang, Song Cao. 1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology , Shanghai 200237, China.
Abstract
A mild and versatile method for the construction of C-N bonds by the reaction of (2,2-difluorovinyl)arenes with various N-H-containing heterocycles in the presence of K3PO4 has been developed. The reaction proceeded efficiently at room temperature (25 °C) affording the (E)-N-α-fluorovinyl derivatives of azoles 3 in good to excellent yields with relatively high stereoselectivity.
A mild and versatile method for the construction of C-N bonds by the reaction of n class="Chemical">(2,2-difluorovinyl)arenes with various N-H-containing heterocycles in the presence of K3PO4 has been developed. The reaction proceeded efficiently at room temperature (25 °C) affording the (E)-N-α-fluorovinyl derivatives of azoles 3 in good to excellent yields with relatively high stereoselectivity.