Literature DB >> 24702118

Evaluation of ALS assay of TB-SA for diagnosis of pulmonary tuberculosis.

Jin Jiao1, Mao-Shui Wang, Xiao-Guang Yang, Xin-Feng Wang.   

Abstract

The study evaluated tuberculosis specific antigen (TB-SA) antibody in lymphocyte supernatant (ALS) assay for diagnosis of pulmonary tuberculosis (PTB). The mean concentration of TB-SA ALS in PTB patients was significantly higher than that of two control groups (non-PTB patients and healthy subjects, P < 0.001). The area under the curve of the ALS assay were 0.960 (0.904-0.988, PTB vs healthy subjects), and were 0.822 (0.739-0.887, PTB vs Non-PTB patients), respectively. Our data indicated the ALS assay for TB-SA can be used as a screening test and is a useful adjunct to current tests for diagnosis of PTB.

Entities:  

Keywords:  antibodies in lymphocyte supernatants; diagnosis; mycobacterium tuberculosis; pulmonary tuberculosis; specific antigen

Mesh：

Substances：

Year:  2015        PMID： 24702118     DOI： 10.1080/15321819.2014.908127

Source DB:  PubMed          Journal:  J Immunoassay Immunochem        ISSN： 1532-1819


  5 in total

Review 1.  The Antibody-Secreting Cell Response to Infection: Kinetics and Clinical Applications.

Authors:  Michael J Carter; Ruth M Mitchell; Patrick M Meyer Sauteur; Dominic F Kelly; Johannes Trück
Journal:  Front Immunol       Date:  2017-06-01       Impact factor: 7.561

2.  Evaluation of the Antibody in Lymphocyte Supernatant Assay to Detect Active Tuberculosis.

Authors:  Margaretha Sariko; Caitlin Anderson; Buliga S Mujaga; Jean Gratz; Stellah G Mpagama; Scott Heysell; Gibson Kibiki; Blandina Mmbaga; Eric Houpt; Tania Thomas
Journal:  PLoS One       Date:  2017-01-13       Impact factor: 3.240

3.  Antibody in Lymphocyte Supernatant (ALS) responses after oral vaccination with live Shigella sonnei vaccine candidates WRSs2 and WRSs3 and correlation with serum antibodies, ASCs, fecal IgA and shedding.

Authors:  Malabi M Venkatesan; Cassandra Ballou; Shoshana Barnoy; Monica McNeal; Jill El-Khorazaty; Robert Frenck; Shahida Baqar
Journal:  PLoS One       Date:  2021-11-18       Impact factor: 3.240

Review 4.  A systematic review of potential screening biomarkers for active TB disease.

Authors:  James H Wykowski; Chris Phillips; Thao Ngo; Paul K Drain
Journal:  J Clin Tuberc Other Mycobact Dis       Date:  2021-11-05

5.  Assessment and Translation of the Antibody-in-Lymphocyte Supernatant (ALS) Assay to Improve the Diagnosis of Enteric Fever in Two Controlled Human Infection Models and an Endemic Area of Nepal.

Authors:  Thomas C Darton; Claire Jones; Sabina Dongol; Merryn Voysey; Christoph J Blohmke; Rajendra Shrestha; Abhilasha Karkey; Mila Shakya; Amit Arjyal; Claire S Waddington; Malick Gibani; Michael J Carter; Buddha Basnyat; Stephen Baker; Andrew J Pollard
Journal:  Front Microbiol       Date:  2017-10-23       Impact factor: 5.640
  5 in total

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