| Literature DB >> 24702025 |
Karoline T Neumann1, Simon R Laursen, Anders T Lindhardt, Benny Bang-Andersen, Troels Skrydstrup.
Abstract
A general procedure for the palladium-catalyzed carbonylative Sonogashira coupling of aryl bromides is reported, using near stoichiometric amounts of carbon monoxide. The method allows a broad substrate scope in moderate to excellent yields. The formed alkynone motive serves as a platform for synthesis of various heterocyclic structures, including pyrimidines. Furthermore, the presented strategy allows effective (13)C labeling.Entities:
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Year: 2014 PMID： 24702025 DOI： 10.1021/ol5007289
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005