Hem Kumar Tamang1, Uddhav Timilsina2, Khelanand Prasad Singh3, Sanjit Shrestha4, Ramendra Kumar Raman5, Pujan Panta6, Preeti Karna6, Laxmi Khadka6, Chandika Dahal7. 1. Lecturer, Department of Biochemistry, Kantipur Dental College Teaching Hospital , Dhapasi, Basundhara, Kathamandu, Nepal . 2. Phd Scholar, Department of Life Sciences and Biotechnology, South Asian University , New Delhi, India . 3. Lecturer, Department of Biochemistry, Institute of Medicine (TUTH) , Maharajgunj, Kathmandu, Nepal . 4. Medical Laboratory Technologist, Department of Pathology, Kathmandu Model Hospital , Exhibition Road, Kathmandu, Nepal . 5. Lecturer, Department of Anatomy, Kantipur Dental college Teaching Hospital , Dhapasi, Basundhara, Kathmandu, Nepal . 6. Faculty, Department of Medical Laboratory Technology, Nobel College , Sinamangal, Kathmandu, Nepal . 7. Faculty, Department of Medical Laboratory Technology, Nobel College , Sinamangal, Kathmandu, Nepal.
Abstract
BACKGROUND: Apo B and Apo A-I, are structural and functional components of lipoprotein particles that serve as transporters of cholesterol. The apo B/apo A-I ratio reflects the cholesterol transport and has been shown to be strongly related to risk of Myocardial infarction, stroke and other Cardiovascular manifestations. MATERIALS AND METHODS: Forty five participants with Cardiovascular Disease (CVD) and forty four healthy participants were included from different locations of Kathmandu valley, Nepal. Fasting blood samples were collected from ante-cubital vein and serum samples were used for lipid parameters, apo B and apo A-I levels measurement. RESULTS: Statistically significant differences were found for apo B/apo A-I ratio, HDL-c and apo B between the groups. The other lipid parameters and lipid ratios such as total cholesterol, triglyceride, low density lipoprotein, TC/HDL-c, TG/HDL-c and LDL-c/HDL-c were not found to be significant. CONCLUSION: Apo B/apo A-I ratio seems to have better predictive value than that of classical lipid parameters in cardiovascular risk assessment.
BACKGROUND:Apo B and Apo A-I, are structural and functional components of lipoprotein particles that serve as transporters of cholesterol. The apo B/apo A-I ratio reflects the cholesterol transport and has been shown to be strongly related to risk of Myocardial infarction, stroke and other Cardiovascular manifestations. MATERIALS AND METHODS: Forty five participants with Cardiovascular Disease (CVD) and forty four healthy participants were included from different locations of Kathmandu valley, Nepal. Fasting blood samples were collected from ante-cubital vein and serum samples were used for lipid parameters, apo B and apo A-I levels measurement. RESULTS: Statistically significant differences were found for apo B/apo A-I ratio, HDL-c and apo B between the groups. The other lipid parameters and lipid ratios such as total cholesterol, triglyceride, low density lipoprotein, TC/HDL-c, TG/HDL-c and LDL-c/HDL-c were not found to be significant. CONCLUSION:Apo B/apo A-I ratio seems to have better predictive value than that of classical lipid parameters in cardiovascular risk assessment.
Entities:
Keywords:
Apo B/apo A-I ratio; Cardiovascular disease; Lipid parameters; Predictive value
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