Literature DB >> 24699473

Japanese encephalitis virus vaccine candidates generated by chimerization with dengue virus type 4.

Gregory D Gromowski1, Cai-Yen Firestone2, Christopher T Hanson2, Stephen S Whitehead2.   

Abstract

Japanese encephalitis virus (JEV) is a leading cause of viral encephalitis worldwide and vaccination is one of the most effective ways to prevent disease. A suitable live-attenuated JEV vaccine could be formulated with a live-attenuated tetravalent dengue vaccine for the control of these viruses in endemic areas. Toward this goal, we generated chimeric virus vaccine candidates by replacing the precursor membrane (prM) and envelope (E) protein structural genes of recombinant dengue virus type 4 (rDEN4) or attenuated vaccine candidate rDEN4Δ30 with those of wild-type JEV strain India/78. Mutations were engineered in E, NS3 and NS4B protein genes to improve replication in Vero cells. The chimeric viruses were attenuated in mice and some elicited modest but protective levels of immunity after a single dose. One particular chimeric virus, bearing E protein mutation Q264H, replicated to higher titer in tissue culture and was significantly more immunogenic in mice. The results are compared with live-attenuated JEV vaccine strain SA14-14-2. Published by Elsevier Ltd.

Entities:  

Keywords:  Chimeric virus; Japanese encephalitis virus; Live-attenuated vaccine

Mesh：

Substances：

Year:  2014        PMID： 24699473      PMCID： PMC4083695          DOI： 10.1016/j.vaccine.2014.03.062

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  47 in total

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Authors:  Mario Lobigs; Eva Lee
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

2.  Phylogenetic analysis suggests only one serotype of Japanese encephalitis virus.

Authors:  S A Tsarev; M L Sanders; D W Vaughn; B L Innis
Journal:  Vaccine       Date:  2000-05-26       Impact factor: 3.641

3.  West Nile virus/dengue type 4 virus chimeras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacy.

Authors:  Alexander G Pletnev; Robert Putnak; Jim Speicher; Eric J Wagar; David W Vaughn
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-05       Impact factor: 11.205

4.  Phylogenetic analysis of Japanese encephalitis virus: envelope gene based analysis reveals a fifth genotype, geographic clustering, and multiple introductions of the virus into the Indian subcontinent.

Authors:  P D Uchil; V Satchidanandam
Journal:  Am J Trop Med Hyg       Date:  2001-09       Impact factor: 2.345

5.  Origin and evolution of Japanese encephalitis virus in southeast Asia.

Authors:  Tom Solomon; Haolin Ni; David W C Beasley; Miquel Ekkelenkamp; Mary Jane Cardosa; Alan D T Barrett
Journal:  J Virol       Date:  2003-03       Impact factor: 5.103

6.  Yellow fever/Japanese encephalitis chimeric viruses: construction and biological properties.

Authors:  T J Chambers; A Nestorowicz; P W Mason; C M Rice
Journal:  J Virol       Date:  1999-04       Impact factor: 5.103

7.  A single dose of any of four different live attenuated tetravalent dengue vaccines is safe and immunogenic in flavivirus-naive adults: a randomized, double-blind clinical trial.

Authors:  Anna P Durbin; Beth D Kirkpatrick; Kristen K Pierce; Daniel Elwood; Catherine J Larsson; Janet C Lindow; Cecilia Tibery; Beulah P Sabundayo; Donna Shaffer; Kawsar R Talaat; Noreen A Hynes; Kimberli Wanionek; Marya P Carmolli; Catherine J Luke; Brian R Murphy; Kanta Subbarao; Stephen S Whitehead
Journal:  J Infect Dis       Date:  2013-01-17       Impact factor: 5.226

8.  A trade-off in replication in mosquito versus mammalian systems conferred by a point mutation in the NS4B protein of dengue virus type 4.

Authors:  Kathryn A Hanley; Luella R Manlucu; Lara E Gilmore; Joseph E Blaney; Christopher T Hanson; Brian R Murphy; Stephen S Whitehead
Journal:  Virology       Date:  2003-07-20       Impact factor: 3.616

9.  Japanese Encephalitis Vaccines.

Authors:  Monica A McArthur; Michael R Holbrook
Journal:  J Bioterror Biodef       Date:  2011-09-25

Review 10.  Structural insights into the mechanisms of antibody-mediated neutralization of flavivirus infection: implications for vaccine development.

Authors:  Theodore C Pierson; Daved H Fremont; Richard J Kuhn; Michael S Diamond
Journal:  Cell Host Microbe       Date:  2008-09-11       Impact factor: 21.023
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  6 in total

1.  Recovery of West Nile Virus Envelope Protein Domain III Chimeras with Altered Antigenicity and Mouse Virulence.

Authors:  Alexander J McAuley; Maricela Torres; Jessica A Plante; Claire Y-H Huang; Dennis A Bente; David W C Beasley
Journal:  J Virol       Date:  2016-04-14       Impact factor: 5.103

2.  Genetic and phenotypic properties of vero cell-adapted Japanese encephalitis virus SA14-14-2 vaccine strain variants and a recombinant clone, which demonstrates attenuation and immunogenicity in mice.

Authors:  Gregory D Gromowski; Cai-Yen Firestone; José Bustos-Arriaga; Stephen S Whitehead
Journal:  Am J Trop Med Hyg       Date:  2014-10-13       Impact factor: 2.345

3.  Genetic Determinants of Japanese Encephalitis Virus Vaccine Strain SA14-14-2 That Govern Attenuation of Virulence in Mice.

Authors:  Gregory D Gromowski; Cai-Yen Firestone; Stephen S Whitehead
Journal:  J Virol       Date:  2015-04-08       Impact factor: 5.103

4.  Cellular Immune Responses to Live Attenuated Japanese Encephalitis (JE) Vaccine SA14-14-2 in Adults in a JE/Dengue Co-Endemic Area.

Authors:  Lance Turtle; Filippo Tatullo; Tanushka Bali; Vasanthapuram Ravi; Mohammed Soni; Sajesh Chan; Savita Chib; Manjunatha M Venkataswamy; Prachi Fadnis; Mansour Yaïch; Stefan Fernandez; Paul Klenerman; Vijaya Satchidanandam; Tom Solomon
Journal:  PLoS Negl Trop Dis       Date:  2017-01-30

Review 5.  Capsid-Targeted Viral Inactivation: A Novel Tactic for Inhibiting Replication in Viral Infections.

Authors:  Xingcui Zhang; Renyong Jia; Jiakun Zhou; Mingshu Wang; Zhongqiong Yin; Anchun Cheng
Journal:  Viruses       Date:  2016-09-21       Impact factor: 5.048

6.  New reverse genetics and transfection methods to rescue arboviruses in mosquito cells.

Authors:  Thérèse Atieh; Antoine Nougairède; Raphaëlle Klitting; Fabien Aubry; Anna-Bella Failloux; Xavier de Lamballerie; Stéphane Priet
Journal:  Sci Rep       Date:  2017-10-25       Impact factor: 4.379
  6 in total

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