Shu-Mei Yan1, Hui-Ni Wu2, Fan He3, Xiao-peng Hu4, Zhi-yi Zhang1, Ma-Yan Huang1, Xiao Wu5, Chun-yu Huang6, Yong Li7. 1. State Key Laboratory of Oncology in South China and Department of Pathology, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China. 2. School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of China. 3. Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China. 4. Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, People's Republic of China. 5. Department of Pathology, Cancer Hospital of Shantou University Medical College, Shantou, People's Republic of China. 6. Department of Endoscopy, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China. 7. State Key Laboratory of Oncology in South China and Department of Pathology, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China. Electronic address: liyong@sysucc.org.cn.
Abstract
BACKGROUND: Zinc-binding protein-89 (ZBP-89), a Krüppel-type four-zinc finger transcription factor, is associated with many cellular functions, including cell growth, differentiation, and apoptosis. It has been reported to be involved in several human cancers. However, ZBP-89 expression pattern and its clinical significance have not yet been investigated in esophageal squamous cell cancer. METHODS: In this study, immunostaining was performed to detect ZBP-89 expression in esophageal squamous cell cancer, and then the correlations between ZBP-89 expression and both clinicopathologic variables and overall survival were analyzed. RESULTS: Compared with adjacent normal tissues, ZBP-89 expression was significantly upregulated in esophageal squamous cell cancer tissues. Increased ZBP-89 expression was associated with N category (p = 0.009) and TNM stage (p = 0.023). Patients with high expression of ZBP-89 demonstrated shortened overall survival compared with those with low expression of ZBP-89 (mean overall survival, 56.961 months versus 76.029 months; p < 0.001). Multivariate Cox regression analysis indicated that ZBP-89 expression had a significant, independent predictive value for survival of esophageal squamous cell cancer (relative risk, 1.581; p = 0.024). CONCLUSIONS: Our data show that increased expression of ZBP-89 is associated with poor prognosis for esophageal squamous cell cancer patients and may act as a novel, useful, and independent prognostic indicator for esophageal squamous cell cancer. Further studies are warranted.
BACKGROUND:Zinc-binding protein-89 (ZBP-89), a Krüppel-type four-zinc finger transcription factor, is associated with many cellular functions, including cell growth, differentiation, and apoptosis. It has been reported to be involved in several humancancers. However, ZBP-89 expression pattern and its clinical significance have not yet been investigated in esophageal squamous cell cancer. METHODS: In this study, immunostaining was performed to detect ZBP-89 expression in esophageal squamous cell cancer, and then the correlations between ZBP-89 expression and both clinicopathologic variables and overall survival were analyzed. RESULTS: Compared with adjacent normal tissues, ZBP-89 expression was significantly upregulated in esophageal squamous cell cancer tissues. Increased ZBP-89 expression was associated with N category (p = 0.009) and TNM stage (p = 0.023). Patients with high expression of ZBP-89 demonstrated shortened overall survival compared with those with low expression of ZBP-89 (mean overall survival, 56.961 months versus 76.029 months; p < 0.001). Multivariate Cox regression analysis indicated that ZBP-89 expression had a significant, independent predictive value for survival of esophageal squamous cell cancer (relative risk, 1.581; p = 0.024). CONCLUSIONS: Our data show that increased expression of ZBP-89 is associated with poor prognosis for esophageal squamous cell cancerpatients and may act as a novel, useful, and independent prognostic indicator for esophageal squamous cell cancer. Further studies are warranted.
Authors: Bryan E Essien; Sinju Sundaresan; Ramon Ocadiz-Ruiz; Aaron Chavis; Amy C Tsao; Arthur J Tessier; Michael M Hayes; Amanda Photenhauer; Milena Saqui-Salces; Anthony J Kang; Yatrik M Shah; Balazs Győrffy; Juanita L Merchant Journal: Cancer Res Date: 2016-10-10 Impact factor: 12.701
Authors: Anna Nilton; Volkan I Sayin; Zhiyuan V Zou; Sama I Sayin; Cecilia Bondjers; Nadia Gul; Pia Agren; Per Fogelstrand; Ola Nilsson; Martin O Bergo; Per Lindahl Journal: Oncotarget Date: 2016-08-30