M Kloss1,2, C Grond-Ginsbach1, A Pezzini3, T M Metso4, A J Metso4, S Debette5,6,7, D Leys6, J Dallongeville7, V Caso8, V Thijs9,10, A Bersano11, E Touzé12, L H Bonati13, T Tatlisumak4, M-L Arnold1, P A Lyrer13, S T Engelter13,14. 1. Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany. 2. Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany. 3. Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy. 4. Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland. 5. Department of Neurology, Hôpital Lariboisière, Paris, France. 6. Department of Neurology, University Lille Nord de France, Lille, France. 7. Department of Epidemiology and Public Health, INSERM U744, Pasteur Institute, Lille, France. 8. Stroke Unit, Perugia University Hospital, Perugia, Italy. 9. Department of Neurosciences, VIB - Vesalius Research Center, Experimental Neurology - Laboratory of Neurobiology, KU Leuven - University of Leuven, Leuven, Belgium. 10. Neurology, University Hospitals Leuven, Leuven, Belgium. 11. Cerebrovascular Unit, IRCCS Foundation C. Besta Neurological Institute, Milan, Italy. 12. Department of Neurology, University of Caen Basse Normandie, INSERM U919, CHU Côte de Nacre, Caen, France. 13. Department of Neurology, Basel University Hospital, Basel, Switzerland. 14. Neurorehabilitation Unit, University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Basel, Switzerland.
Abstract
BACKGROUND AND PURPOSE: Patients with ischaemic stroke (IS) caused by a spontaneous cervical artery dissection (CeAD) worry about an increased risk for stroke in their families. The occurrence of stroke in relatives of patients with CeAD and in those with ischaemic stroke attributable to other (non-CeAD) causes were compared. METHODS: The frequency of stroke in first-degree relatives (family history of stroke, FHS) was studied in IS patients (CeAD patients and age- and sex-matched non-CeAD patients) from the Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) database. FHS ≤ 50 and FHS > 50 were defined as having relatives who suffered stroke at the age of ≤50 or >50 years. FHS ≤ 50 and FHS > 50 were studied in CeAD and non-CeAD IS patients and related to age, sex, number of siblings, hypertension, hypercholesterolemia, smoking and body mass index (BMI). RESULTS: In all, 1225 patients were analyzed. FHS ≤ 50 was less frequent in CeAD patients (15/598 = 2.5%) than in non-CeAD IS patients (38/627 = 6.1%) (P = 0.003; odds ratio 0.40, 95% confidence interval 0.22-0.73), also after adjustment for age, sex and number of siblings (P = 0.005; odds ratio 0.42, 95% confidence interval 0.23-0.77). The frequency of FHS > 50 was similar in both study groups. Vascular risk factors did not differ between patients with positive or negative FHS ≤ 50. However, patients with FHS > 50 were more likely to have hypertension and higher BMI. CONCLUSION: Relatives of CeAD patients had fewer strokes at a young age than relatives of non-CeAD IS stroke patients.
BACKGROUND AND PURPOSE:Patients with ischaemic stroke (IS) caused by a spontaneous cervical artery dissection (CeAD) worry about an increased risk for stroke in their families. The occurrence of stroke in relatives of patients with CeAD and in those with ischaemic stroke attributable to other (non-CeAD) causes were compared. METHODS: The frequency of stroke in first-degree relatives (family history of stroke, FHS) was studied in IS patients (CeAD patients and age- and sex-matched non-CeAD patients) from the Cervical Artery Dissection and Ischemic StrokePatients (CADISP) database. FHS ≤ 50 and FHS > 50 were defined as having relatives who suffered stroke at the age of ≤50 or >50 years. FHS ≤ 50 and FHS > 50 were studied in CeAD and non-CeAD IS patients and related to age, sex, number of siblings, hypertension, hypercholesterolemia, smoking and body mass index (BMI). RESULTS: In all, 1225 patients were analyzed. FHS ≤ 50 was less frequent in CeAD patients (15/598 = 2.5%) than in non-CeAD IS patients (38/627 = 6.1%) (P = 0.003; odds ratio 0.40, 95% confidence interval 0.22-0.73), also after adjustment for age, sex and number of siblings (P = 0.005; odds ratio 0.42, 95% confidence interval 0.23-0.77). The frequency of FHS > 50 was similar in both study groups. Vascular risk factors did not differ between patients with positive or negative FHS ≤ 50. However, patients with FHS > 50 were more likely to have hypertension and higher BMI. CONCLUSION: Relatives of CeAD patients had fewer strokes at a young age than relatives of non-CeAD IS strokepatients.
Authors: Caspar Grond-Ginsbach; Tobias Brandt; Manja Kloss; Suna Su Aksay; Philipp Lyrer; Christopher Traenka; Philipp Erhart; Juan Jose Martin; Ayse Altintas; Aksel Siva; Gabriel R de Freitas; Andreas Thie; Jochen Machetanz; Ralf W Baumgartner; Martin Dichgans; Stefan T Engelter Journal: Eur Stroke J Date: 2017-02-09
Authors: Reetta Kivioja; Arto Pietilä; Nicolas Martinez-Majander; Daniel Gordin; Aki S Havulinna; Veikko Salomaa; Karoliina Aarnio; Sami Curtze; Jaana Leiviskä; Jorge Rodríguez-Pardo; Ida Surakka; Markku Kaste; Turgut Tatlisumak; Jukka Putaala Journal: J Am Heart Assoc Date: 2018-11-06 Impact factor: 5.501