Literature DB >> 24698125

Telomere shortening in neurological disorders: an abundance of unanswered questions.

Erez Eitan1, Emmette R Hutchison1, Mark P Mattson2.   

Abstract

Telomeres, ribonucleoprotein complexes that cap eukaryotic chromosomes, typically shorten in leukocytes with aging. Aging is a primary risk factor for neurodegenerative disease (ND), and a common assumption has arisen that leukocyte telomere length (LTL) can serve as a predictor of neurological disease. However, the evidence for shorter LTL in Alzheimer's and Parkinson's patients is inconsistent. The diverse causes of telomere shortening may explain variability in LTL between studies and individuals. Additional research is needed to determine whether neuronal and glial telomeres shorten during aging and in neurodegenerative disorders, if and how LTL is related to brain cell telomere shortening, and whether telomere shortening plays a causal role in or exacerbates neurological disorders. Published by Elsevier Ltd.

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Year:  2014        PMID： 24698125      PMCID： PMC4008659          DOI： 10.1016/j.tins.2014.02.010

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  101 in total

1.  Telomere shortening in T cells correlates with Alzheimer's disease status.

Authors:  L A Panossian; V R Porter; H F Valenzuela; X Zhu; Erin Reback; D Masterman; J L Cummings; R B Effros
Journal:  Neurobiol Aging       Date:  2003 Jan-Feb       Impact factor: 4.673

2.  Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia.

Authors:  Lawrence S Honig; Nicole Schupf; Joseph H Lee; Ming X Tang; Richard Mayeux
Journal:  Ann Neurol       Date:  2006-08       Impact factor: 10.422

3.  The rate of increase of short telomeres predicts longevity in mammals.

Authors:  Elsa Vera; Bruno Bernardes de Jesus; Miguel Foronda; Juana M Flores; Maria A Blasco
Journal:  Cell Rep       Date:  2012-09-27       Impact factor: 9.423

4.  Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.

Authors:  Mariela Jaskelioff; Florian L Muller; Ji-Hye Paik; Emily Thomas; Shan Jiang; Andrew C Adams; Ergun Sahin; Maria Kost-Alimova; Alexei Protopopov; Juan Cadiñanos; James W Horner; Eleftheria Maratos-Flier; Ronald A Depinho
Journal:  Nature       Date:  2010-11-28       Impact factor: 49.962

5.  Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy?

Authors:  Sonia Franco; Maria A Blasco; Sandra L Siedlak; Peggy L R Harris; Paula I Moreira; George Perry; Mark A Smith
Journal:  Alzheimers Dement       Date:  2006-07       Impact factor: 21.566

6.  Human naive and memory T lymphocytes differ in telomeric length and replicative potential.

Authors:  N P Weng; B L Levine; C H June; R J Hodes
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

7.  Association between telomere length in blood and mortality in people aged 60 years or older.

Authors:  Richard M Cawthon; Ken R Smith; Elizabeth O'Brien; Anna Sivatchenko; Richard A Kerber
Journal:  Lancet       Date:  2003-02-01       Impact factor: 79.321

8.  No evidence of substantia nigra telomere shortening in Parkinson's disease.

Authors:  Gavin Hudson; David Faini; Andrea Stutt; Martin Eccles; Louise Robinson; David J Burn; Patrick F Chinnery
Journal:  Neurobiol Aging       Date:  2011-07-27       Impact factor: 4.673

9.  Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options.

Authors:  Bayani Uttara; Ajay V Singh; Paolo Zamboni; R T Mahajan
Journal:  Curr Neuropharmacol       Date:  2009-03       Impact factor: 7.363

Review 10.  Prion-like spread of protein aggregates in neurodegeneration.

Authors:  Magdalini Polymenidou; Don W Cleveland
Journal:  J Exp Med       Date:  2012-05-07       Impact factor: 14.307
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  48 in total

1.  Excitotoxic and Radiation Stress Increase TERT Levels in the Mitochondria and Cytosol of Cerebellar Purkinje Neurons.

Authors:  Erez Eitan; Carmel Braverman; Ailone Tichon; Daniel Gitler; Emmette R Hutchison; Mark P Mattson; Esther Priel
Journal:  Cerebellum       Date:  2016-08       Impact factor: 3.847

2.  Telomere attrition is associated with declines in medial temporal lobe volume and white matter microstructure in functionally independent older adults.

Authors:  Adam M Staffaroni; Duygu Tosun; Jue Lin; Fanny M Elahi; Kaitlin B Casaletto; Matthew J Wynn; Nihar Patel; John Neuhaus; Samantha M Walters; Elissa S Epel; Elizabeth H Blackburn; Joel H Kramer
Journal:  Neurobiol Aging       Date:  2018-05-08       Impact factor: 4.673

Review 3.  Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.

Authors:  Daniel Lindqvist; Elissa S Epel; Synthia H Mellon; Brenda W Penninx; Dóra Révész; Josine E Verhoeven; Victor I Reus; Jue Lin; Laura Mahan; Christina M Hough; Rebecca Rosser; F Saverio Bersani; Elizabeth H Blackburn; Owen M Wolkowitz
Journal:  Neurosci Biobehav Rev       Date:  2015-05-18       Impact factor: 8.989

4.  Relative telomere length is associated with a functional polymorphism in the monoamine oxidase A gene in a South American sample.

Authors:  César A Speck-Hernández; Diego A Ojeda; Luis J Castro-Vega; Diego A Forero
Journal:  J Genet       Date:  2015-06       Impact factor: 1.166

Review 5.  Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain.

Authors:  Grasiella A Andriani; Jan Vijg; Cristina Montagna
Journal:  Mech Ageing Dev       Date:  2016-03-21       Impact factor: 5.432

6.  Leukocyte Telomere Length Is Unrelated to Cognitive Performance Among Non-Demented and Demented Persons: An Examination of Long Life Family Study Participants.

Authors:  Adiba Ashrafi; Stephanie Cosentino; Min S Kang; Joseph H Lee; Nicole Schupf; Stacy L Andersen; Kaare Christensen; Michael A Province; Bharat Thyagarajan; Joseph M Zmuda; Lawrence S Honig
Journal:  J Int Neuropsychol Soc       Date:  2020-04-28       Impact factor: 2.892

7.  Effects of Meditation and Music-Listening on Blood Biomarkers of Cellular Aging and Alzheimer's Disease in Adults with Subjective Cognitive Decline: An Exploratory Randomized Clinical Trial.

Authors:  Kim E Innes; Terry Kit Selfe; Kathleen Brundage; Caitlin Montgomery; Sijin Wen; Sahiti Kandati; Hannah Bowles; Dharma Singh Khalsa; Zenzi Huysmans
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

8.  Meta-analysis of Telomere Length in Alzheimer's Disease.

Authors:  Diego A Forero; Yeimy González-Giraldo; Catalina López-Quintero; Luis J Castro-Vega; George E Barreto; George Perry
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2016-04-18       Impact factor: 6.053

9.  Telomere length in Parkinson's disease: A meta-analysis.

Authors:  Diego A Forero; Yeimy González-Giraldo; Catalina López-Quintero; Luis J Castro-Vega; George E Barreto; George Perry
Journal:  Exp Gerontol       Date:  2016-01-07       Impact factor: 4.032

10.  Connecting cognition, cardiology, and chromosomes: Cognitive reappraisal impacts the relationship between heart rate variability and telomere length in CD8+CD28- cells.

Authors:  Anoushka D Shahane; Angie S LeRoy; Bryan T Denny; Christopher P Fagundes
Journal:  Psychoneuroendocrinology       Date:  2019-11-14       Impact factor: 4.905
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