Celine Akyurekli1, Joshua Y S Chan, Heidi Elmoazzen, Jason Tay, David S Allan. 1. Blood and Marrow Transplant Program, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Abstract
BACKGROUND: How ethnicity impacts characteristics of umbilical cord blood collected by cord blood banks remains unclear. STUDY DESIGN AND METHODS: After a systematic search, we identified 11 studies for analysis that reported on various variables of collected cord blood units. RESULTS: Non-Caucasian ethnicity of the cord blood donor was associated with a higher risk of failing to meet banking criteria, lower cord blood volume, reduced total nucleated cell count, fewer CD34+ cells, and reduced colony-forming units. CONCLUSIONS: Non-Caucasian ethnicity is associated with reductions in hematopoietic measures of collected cord blood units. Public banking efforts will have to balance issues related to building ethnic diversity within the bank and maintaining the characteristics of banked units that remain desirable by transplant centers.
BACKGROUND: How ethnicity impacts characteristics of umbilical cord blood collected by cord blood banks remains unclear. STUDY DESIGN AND METHODS: After a systematic search, we identified 11 studies for analysis that reported on various variables of collected cord blood units. RESULTS: Non-Caucasian ethnicity of the cord blood donor was associated with a higher risk of failing to meet banking criteria, lower cord blood volume, reduced total nucleated cell count, fewer CD34+ cells, and reduced colony-forming units. CONCLUSIONS: Non-Caucasian ethnicity is associated with reductions in hematopoietic measures of collected cord blood units. Public banking efforts will have to balance issues related to building ethnic diversity within the bank and maintaining the characteristics of banked units that remain desirable by transplant centers.
Authors: C Bordoni; J Magalon; C Gilbertas; M Gamerre; P Le Coz; M Berthomieu; C Chabannon; J Di Cristofaro; C Picard Journal: Bone Marrow Transplant Date: 2015-01-26 Impact factor: 5.483
Authors: Ioannis Politikos; Christopher M Mazis; Kristine A Naputo; Kelcey Skinner; Melissa Nhaissi; Eric Davis; Andromachi Scaradavou; Juliet N Barker Journal: Bone Marrow Transplant Date: 2020-08-29 Impact factor: 5.483