| Literature DB >> 24697791 |
Zhihai Ke1, Chong Kiat Tan, Feng Chen, Ying-Yeung Yeung.
Abstract
An enantioselective and highly diastereoselective bromoetherification and desymmetrization of olefinic 1,3-diols has been developed using a C2-symmetric cyclic sulfide catalyst. This methodology has been successfully applied to the synthesis of the key intermediate of an orally active antifungal drug posaconazole (Noxafil).Entities:
Year: 2014 PMID： 24697791 DOI： 10.1021/ja5029155
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419