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Literature DB >> 24697653

IL-6 in diabetes and cardiovascular complications.

Dan Qu¹, Jian Liu, Chi Wai Lau, Yu Huang.

Abstract

IL-6 is a pleiotropic cytokine that participates in normal functions of the immune system, haematopoiesis, metabolism, as well as in the pathogenesis of metabolic and cardiovascular diseases. Both pro- and anti-inflammatory roles of IL-6 have been described, which are distinguished by different cascades of signalling transduction, namely classic and trans-signalling. The present review summarizes the basic principles of IL-6 signalling and discusses its roles in diabetes and associated cardiovascular complications, with emphasis on the different outcomes mediated by the two modes of IL-6 signalling and the value of developing therapeutic strategies to specifically target the deleterious trans-signalling of IL-6.

Entities: Disease Gene

Keywords: cardiovascular diseases; diabetes; inflammation; interleukin-6

Mesh：

Substances：
Interleukin-6

Year: 2014 PMID： 24697653 PMCID： PMC4128059 DOI： 10.1111/bph.12713

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

79 in total

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51 in total

1. Single administration of recombinant IL-6 restores the gene expression of lipogenic enzymes in liver of fasting IL-6-deficient mice.

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Journal: CEN Case Rep Date: 2020-07-17

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Journal: Chin J Integr Med Date: 2020-11-19 Impact factor: 1.978

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Journal: Cardiovasc Endocrinol Metab Date: 2019-09-10

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Journal: Cell Mol Immunol Date: 2021-01-08 Impact factor: 11.530

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Journal: Hum Mol Genet Date: 2021-04-27 Impact factor: 6.150

9. Characterisation of baseline microbiological and host factors in an inception cohort of people with surgical wounds healing by secondary intention reveals circulating IL-6 levels as a potential predictive biomarker of healing.

Authors: Hannah Buckley; Jo Dumville; Michael Hodgkinson; Debbie Wearmouth; Gavin Barlow; Marjan van der Woude; Nicky Cullum; Ian Chetter; Dimitris Lagos
Journal: Wellcome Open Res Date: 2020-11-19

10. Effects of a Self-Prepared Carbohydrate-Reduced High-Protein Diet on Cardiovascular Disease Risk Markers in Patients with Type 2 Diabetes.

Authors: Ahmad H Alzahrani; Mads J Skytte; Amirsalar Samkani; Mads N Thomsen; Arne Astrup; Christian Ritz; Jan Frystyk; Jens J Holst; Sten Madsbad; Steen B Haugaard; Thure Krarup; Thomas M Larsen; Faidon Magkos
Journal: Nutrients Date: 2021-05-17 Impact factor: 5.717