Literature DB >> 24697346

Scar prevention and remodeling: a review of the medical, surgical, topical and light treatment approaches.

Leonard Y Kerwin1, Abdel Kader El Tal, Mark A Stiff, Tarek M Fakhouri.   

Abstract

Cosmetic, functional, and structural sequelae of scarring are innumerable, and measures exist to optimize and ultimately minimize these sequelae. To evaluate the innumerable methods available to decrease the cosmetic, functional, and structural repercussions of scarring, pubMed search of the English literature with key words scar, scar revision, scar prevention, scar treatment, scar remodeling, cicatrix, cicatrix treatment, and cicatrix remodeling was done. Original articles and reviews were examined and included. Seventy-nine manuscripts were reviewed. Techniques, comparisons, and results were reviewed and tabulated. Overall, though topical modalities are easier to use and are usually more attractive to the patient, the surgical approaches still prove to be superior and more reliable. However, advances in topical medications for scar modification are on the rise and a change towards medical treatment of scars may emerge as the next best approach. Comparison studies of the innumerable specific modalities for scar revision and prevention are impossible. Standardization of techniques is lacking. Scarring, the body's natural response to a wound, can create many adverse effects. At this point, the practice of sound, surgical fundamentals still trump the most advanced preventative methods and revision techniques. Advances in medical approaches are available, however, to assist the scarring process, which even the most advanced surgical fundamentals will ultimately lead to. Whether through newer topical therapies, light treatment, or classical surgical intervention, our treatment armamentarium of scars has expanded and will allow us to maximize scar prevention and to minimize scar morbidity.
© 2014 The International Society of Dermatology.

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Year:  2014        PMID: 24697346     DOI: 10.1111/ijd.12436

Source DB:  PubMed          Journal:  Int J Dermatol        ISSN: 0011-9059            Impact factor:   2.736


  15 in total

Review 1.  The Northwestern Abdominoplasty Scar Model: A Tool for High-Throughput Assessment of Scar Therapeutics.

Authors:  Ji-Cheng Hsieh; Chitang J Joshi; Rou Wan; Robert D Galiano
Journal:  Adv Wound Care (New Rochelle)       Date:  2020-04-29       Impact factor: 4.730

2.  LIBERTI: A SMART study in plastic surgery.

Authors:  Jonathan C Hibbard; Jonathan S Friedstat; Sonia M Thomas; Renee E Edkins; C Scott Hultman; Michael R Kosorok
Journal:  Clin Trials       Date:  2018-03-25       Impact factor: 2.486

Review 3.  Hypertrophic scarring: the greatest unmet challenge after burn injury.

Authors:  Celeste C Finnerty; Marc G Jeschke; Ludwik K Branski; Juan P Barret; Peter Dziewulski; David N Herndon
Journal:  Lancet       Date:  2016-10-01       Impact factor: 79.321

4.  Angiotensin-converting enzyme inhibitor works as a scar formation inhibitor by down-regulating Smad and TGF-β-activated kinase 1 (TAK1) pathways in mice.

Authors:  Wei-Qiang Tan; Qing-Qing Fang; Xiao Z Shen; Jorge F Giani; Tuantuan V Zhao; Peng Shi; Li-Yun Zhang; Zakir Khan; You Li; Liang Li; Ji-Hua Xu; Ellen A Bernstein; Kenneth E Bernstein
Journal:  Br J Pharmacol       Date:  2018-10-08       Impact factor: 8.739

5.  Light emitting diode-red light for reduction of post-surgical scarring: Results from a dose-ranging, split-face, randomized controlled trial.

Authors:  Alana Kurtti; Julie K Nguyen; Jeremy Weedon; Andrew Mamalis; Yi Lai; Natasha Masub; Amaris Geisler; Daniel M Siegel; Jared R Jagdeo
Journal:  J Biophotonics       Date:  2021-05-04       Impact factor: 3.207

6.  Angiotensin-converting enzyme inhibitor reduces scar formation by inhibiting both canonical and noncanonical TGF-β1 pathways.

Authors:  Qing-Qing Fang; Xiao-Feng Wang; Wan-Yi Zhao; Shi-Li Ding; Bang-Hui Shi; Ying Xia; Hu Yang; Li-Hong Wu; Cai-Yun Li; Wei-Qiang Tan
Journal:  Sci Rep       Date:  2018-02-20       Impact factor: 4.379

7.  Time Heals all Wounds- but Scars Remain. Can Personalized Medicine Help?

Authors:  Saeid Amini-Nik
Journal:  Front Genet       Date:  2018-06-22       Impact factor: 4.599

8.  Exosomes derived from clinical-grade oral mucosal epithelial cell sheets promote wound healing.

Authors:  Sebastian Sjöqvist; Taichi Ishikawa; Daisuke Shimura; Yoshiyuki Kasai; Aya Imafuku; Sophia Bou-Ghannam; Takanori Iwata; Nobuo Kanai
Journal:  J Extracell Vesicles       Date:  2019-01-20

9.  A Prospective Randomized Double-blind study of silicone gel plus Herbal Extracts Versus Placebo in Pre-sternal hypertrophic scar prevention and amelioration.

Authors:  Palakorn Surakunprapha; Kengkart Winaikosol; Bowornsilp Chowchuen; Puttama Punyavong; Kriangsak Jenwitheesuk; Kamonwan Jenwitheesuk
Journal:  Heliyon       Date:  2020-05-05

Review 10.  Skin Care Management For Medical And Aesthetic Procedures To Prevent Scarring.

Authors:  Marie Jourdan; Diane C Madfes; Emerson Lima; Yan Tian; Sophie Seité
Journal:  Clin Cosmet Investig Dermatol       Date:  2019-10-25
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