Ki-Han Kim1, Yoo-Min Kim1, Min-Chan Kim1, Ghap-Joong Jung1. 1. Ki-Han Kim, Yoo-Min Kim, Min-Chan Kim, Ghap-Joong Jung, Department of Surgery, Dong-A University College of Medicine, Busan 602-715, South Korea.
Abstract
AIM: To understand the clinicopathological and prognostic features of gastric cancer in younger and older patients. METHODS: Between January 2002 and December 2008, 1667 patients underwent curative gastric surgery. For comparative purposes, the patients were divided into two groups: younger patients who were less than 40 years old (112 patients), and older patients who were 40 years old and older (1555 patients). In both groups, propensity scoring methods were used to select patients with similar disease statuses. A total of 224 matched cases, with 112 patients in each group, were included in the final analysis. RESULTS: Compared to the older group, the younger group with gastric cancer had a significantly higher percentage of females (P = 0.007), poorly differentiated or signet ring cell carcinoma (P < 0.001), advanced T stage gastric cancer (P = 0.045), and advanced tumor-node-metastasis stage cancer (P = 0.036). The older group with gastric cancer had more comorbidities (P < 0.001). With the exception of the number of lymph node dissection (P < 0.001) and retrieved lymph node (P = 0.010), there were no statistically significant differences between the postoperative outcomes of the two groups. During the follow-up period, there were 19 recurrences in the younger group and 11 recurrences in the older group. The overall five-year survival rates in the younger and older groups were 84.3% and 89.6%, respectively (P = 0.172). There were no significant differences (P = 0.238) in the overall survival of patients with advanced T stage gastric cancer in the two groups, with five-year survival rates of 70.8% in the younger group and 79.5% in the older group. With regard to the age-adjusted survival rate, there was significant difference between the two groups (P = 0.225). CONCLUSION: In spite of aggressive cancer patterns in the younger group with gastric cancer, the younger group did not have a worse prognosis than the older group in our study.
AIM: To understand the clinicopathological and prognostic features of gastric cancer in younger and older patients. METHODS: Between January 2002 and December 2008, 1667 patients underwent curative gastric surgery. For comparative purposes, the patients were divided into two groups: younger patients who were less than 40 years old (112 patients), and older patients who were 40 years old and older (1555 patients). In both groups, propensity scoring methods were used to select patients with similar disease statuses. A total of 224 matched cases, with 112 patients in each group, were included in the final analysis. RESULTS: Compared to the older group, the younger group with gastric cancer had a significantly higher percentage of females (P = 0.007), poorly differentiated or signet ring cell carcinoma (P < 0.001), advanced T stage gastric cancer (P = 0.045), and advanced tumor-node-metastasis stage cancer (P = 0.036). The older group with gastric cancer had more comorbidities (P < 0.001). With the exception of the number of lymph node dissection (P < 0.001) and retrieved lymph node (P = 0.010), there were no statistically significant differences between the postoperative outcomes of the two groups. During the follow-up period, there were 19 recurrences in the younger group and 11 recurrences in the older group. The overall five-year survival rates in the younger and older groups were 84.3% and 89.6%, respectively (P = 0.172). There were no significant differences (P = 0.238) in the overall survival of patients with advanced T stage gastric cancer in the two groups, with five-year survival rates of 70.8% in the younger group and 79.5% in the older group. With regard to the age-adjusted survival rate, there was significant difference between the two groups (P = 0.225). CONCLUSION: In spite of aggressive cancer patterns in the younger group with gastric cancer, the younger group did not have a worse prognosis than the older group in our study.
Authors: K Kitamura; T Yamaguchi; K Yamamoto; D Ichikawa; H Taniguchi; A Hagiwara; K Sawai; T Takahashi Journal: Hepatogastroenterology Date: 1996 Sep-Oct
Authors: J H Choi; H C Chung; N C Yoo; H R Lee; K H Lee; J H Kim; J K Roh; C S Park; J S Min; K S Lee; B S Kim; H Y Lim Journal: Am J Clin Oncol Date: 1996-02 Impact factor: 2.339
Authors: K Nakamura; T Ueyama; T Yao; Z X Xuan; K Ambe; Y Adachi; Y Yakeishi; A Matsukuma; M Enjoji Journal: Cancer Date: 1992-09-01 Impact factor: 6.860
Authors: Nick Pavlakis; Katrin M Sjoquist; Andrew J Martin; Eric Tsobanis; Sonia Yip; Yoon-Koo Kang; Yung-Jue Bang; Thierry Alcindor; Christopher J O'Callaghan; Margot J Burnell; Niall C Tebbutt; Sun Young Rha; Jeeyun Lee; Jae-Yong Cho; Lara R Lipton; Mark Wong; Andrew Strickland; Jin Won Kim; John R Zalcberg; John Simes; David Goldstein Journal: J Clin Oncol Date: 2016-06-20 Impact factor: 44.544
Authors: Brian De; Ryan Rhome; Vikram Jairam; Umut Özbek; Randall F Holcombe; Michael Buckstein; Celina Ang Journal: Gastric Cancer Date: 2018-04-24 Impact factor: 7.370