Literature DB >> 2469641

An in vitro model of allergen-dependent IgE synthesis by human B lymphocytes: comparison of the response of an atopic and a non-atopic individual to Dermatophagoides spp. (house dust mite).

R E O'Hehir1, V Bal, D Quint, R Moqbel, A B Kay, E D Zanders, J R Lamb.   

Abstract

An allergen-dependent in vitro model of immunoglobulin E (IgE) synthesis by human B cells is reported. Using this model, it is demonstrated that polyclonal T cells and CD4+ Dermatophagoides spp. (house dust mite)-specific T-cell clones derived from an atopic, house dust mite (HDM)-allergic individual are able to support IgE synthesis by autologous B cells. The helper activity was interleukin-4 (IL-4) dependent as only cloned T cells expressing detectable mRNA for IL-4 were able to induce IgE synthesis without the addition of exogenous IL-4. Peripheral and cloned T cells reactive with HDM could also be identified from a non-atopic individual but neither population was able to support IgE production even in the presence of exogenous IL-4.

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Year:  1989        PMID： 2469641      PMCID： PMC1385148     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  30 in total

1.  Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell.

Authors:  P J Gearhart; N H Sigal; N R Klinman
Journal:  Proc Natl Acad Sci U S A       Date:  1975-05       Impact factor: 11.205

2.  Cloned human T lymphocytes reactive with Dermatophagoides farinae (house dust mite): a comparison of T- and B-cell antigen recognition.

Authors:  R E O'Hehir; D B Young; A B Kay; J R Lamb
Journal:  Immunology       Date:  1987-12       Impact factor: 7.397

3.  IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

Authors:  G Del Prete; E Maggi; P Parronchi; I Chrétien; A Tiri; D Macchia; M Ricci; J Banchereau; J De Vries; S Romagnani
Journal:  J Immunol       Date:  1988-06-15       Impact factor: 5.422

4.  Structural model of HLA-DR1 restricted T cell antigen recognition.

Authors:  J B Rothbard; R I Lechler; K Howland; V Bal; D D Eckels; R Sekaly; E O Long; W R Taylor; J R Lamb
Journal:  Cell       Date:  1988-02-26       Impact factor: 41.582

5.  Quick-blot: selective mRNA or DNA immobilization from whole cells.

Authors:  J Bresser; J Doering; D Gillespie
Journal:  DNA       Date:  1983

6.  Serum IgD and IgE concentrations in immunodeficiency diseases.

Authors:  R H Buckley; S A Fiscus
Journal:  J Clin Invest       Date:  1975-01       Impact factor: 14.808

Review 7.  Regulation of the human IgE antibody response.

Authors:  D Y Leung; R S Geha
Journal:  Int Rev Immunol       Date:  1987-01       Impact factor: 5.311

8.  T cell clones providing helper function for IgE synthesis release soluble factor(s) that induce IgE production in human B cells: possible role for interleukin 4 (IL-4).

Authors:  E Maggi; G F Del Prete; A Tiri; D Macchia; P Parronchi; M Ricci; S Romagnani
Journal:  Clin Exp Immunol       Date:  1988-07       Impact factor: 4.330

9.  Functional evidence for a monoclonal antibody that binds to the human IL-4 receptor.

Authors:  M Larche; J R Lamb; R E O'Hehir; N Imami-Shita; E D Zanders; D E Quint; R Moqbel; M A Ritter
Journal:  Immunology       Date:  1988-12       Impact factor: 7.397

10.  Fine specificity of regulatory T cells. II. Suppressor and helper T cells are induced by different regions of hen egg-white lysozyme in a genetically nonresponder mouse strain.

Authors:  L Adorini; M A Harvey; A Miller; E E Sercarz
Journal:  J Exp Med       Date:  1979-08-01       Impact factor: 14.307
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  11 in total

1.  Analysis of T-cell epitopes of Der f3 in Dermatophagoides farina.

Authors:  Na Li; Haifeng Xu; Hongyu Song; Kexia Wang; Chaopin Li
Journal:  Int J Clin Exp Pathol       Date:  2015-01-01

2.  Cytokine regulation of antigen-driven immunoglobulin production in filarial parasite infections in humans.

Authors:  C L King; E A Ottesen; T B Nutman
Journal:  J Clin Invest       Date:  1990-06       Impact factor: 14.808

Review 3.  T and B cell responses to HDM allergens and antigens.

Authors:  Wayne R Thomas; Belinda J Hales
Journal:  Immunol Res       Date:  2007       Impact factor: 2.829

4.  In vivo clonal dominance and limited T-cell receptor usage in human CD4+ T-cell recognition of house dust mite allergens.

Authors:  L R Wedderburn; R E O'Hehir; C R Hewitt; J R Lamb; M J Owen
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

5.  Spontaneous expression of IL-4 mRNA in lymphocytes from children with atopic dermatitis.

Authors:  M L Tang; A S Kemp
Journal:  Clin Exp Immunol       Date:  1994-09       Impact factor: 4.330

6.  Dual action of IL-4 on mite antigen-induced IgE synthesis in lymphocytes from individuals with bronchial asthma.

Authors:  Y Kawano; T Noma
Journal:  Clin Exp Immunol       Date:  1995-11       Impact factor: 4.330

7.  Major histocompatibility complex (MHC) class II restriction, lymphokine production, and IgE regulation of house dust mite-specific T-cell clones.

Authors:  K L Lin; K H Hsieh; J H Huang; S Y Wang
Journal:  J Clin Immunol       Date:  1992-07       Impact factor: 8.317

8.  Abnormal immunoglobulin G subclass production in response to keyhole limpet haemocyanin in atopic patients.

Authors:  A E Falconer; P S Friedmann; P Bird; J E Calvert
Journal:  Clin Exp Immunol       Date:  1992-09       Impact factor: 4.330

9.  Polyclonal and clonal analysis of human CD4+ T-lymphocyte responses to nut extracts.

Authors:  J A Higgins; J R Lamb; R A Lake; R E O'Hehir
Journal:  Immunology       Date:  1995-01       Impact factor: 7.397

10.  Functional characterization of lymphocyte response to fractionated house dust mite antigens (Dermatophagoides pteronyssinus) in atopic and non-atopic individuals.

Authors:  J Y Kimura; N Ohta; A Ishii; T Nagano; M Usui
Journal:  Immunology       Date:  1990-07       Impact factor: 7.397
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