Literature DB >> 24695818

Morules in fundic gland polyposis: a case report.

Giovanni De Petris1, Longwen Chen1.   

Abstract

Morular metaplasia has been exceptionally described in the stomach. We report the formation of morules in a case of sporadic fundic gland polyposis with low grade dysplasia in a 47 year old woman that underwent total gastrectomy. The immunophenotype of the morules was CD10, CDX2, Beta-catenin nuclear positive; p63, Ki67, chromogranin, synaptophysin, Ck20 negative. The presence of morules in a neoplasm know to be associated with the disruption of wnt/β-catenin pathway is discussed. The report provides the first description of the immunophenotype of morules in the stomach and hypothesizes the biological similitude of fundic gland polyposis to other tumors characterized by morules formation and wnt/β-catenin pathway dysfunction.

Entities:  

Keywords:  Fundic gland polyp; beta-catenin; morules

Mesh：

Substances：

Year:  2014        PMID： 24695818      PMCID： PMC3971335     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  18 in total

1.  Fundic gland polyps: common and occasionally problematic lesions.

Authors:  Susan C Abraham
Journal:  Gastroenterol Hepatol (N Y)       Date:  2010-01

2.  CD10 is a characteristic marker of tumours forming morules with biotin-rich, optically clear nuclei that occur in different organs.

Authors:  J Cameselle-Teijeiro; L Alberte-Lista; S Chiarelli; C Buriticá; L Gonçalves; R González-Cámpora; F F Nogales
Journal:  Histopathology       Date:  2007-12-13       Impact factor: 5.087

3.  Squamous morules in gastric mucosa.

Authors:  D C Schlosnagle; R D Hardin
Journal:  J Clin Gastroenterol       Date:  1988-06       Impact factor: 3.062

Review 4.  Pseudoneoplasms of the gastrointestinal tract.

Authors:  Giovanni De Petris; Stanley T Leung
Journal:  Arch Pathol Lab Med       Date:  2010-03       Impact factor: 5.534

5.  Beta-catenin mutations in pulmonary blastomas: association with morule formation.

Authors:  Shigeki Sekine; Tatsuhiro Shibata; Yoshihiro Matsuno; Arafumi Maeshima; Genichiro Ishii; Michiie Sakamoto; Setsuo Hirohashi
Journal:  J Pathol       Date:  2003-06       Impact factor: 7.996

6.  Aberrant Cdx2 expression in endometrial lesions with squamous differentiation: important role of Cdx2 in squamous morula formation.

Authors:  Yoji Wani; Kenji Notohara; Makoto Saegusa; Choutatsu Tsukayama
Journal:  Hum Pathol       Date:  2008-05-20       Impact factor: 3.466

7.  Sporadic fundic gland polyposis: a clinical, histological, and molecular analysis.

Authors:  Michael Torbenson; Jae-Hyuk Lee; Marcia Cruz-Correa; William Ravich; Khosrow Rastgar; Susan C Abraham; Tsung-Teh Wu
Journal:  Mod Pathol       Date:  2002-07       Impact factor: 7.842

8.  Morules in endometrioid proliferations of the uterus and ovary consistently express the intestinal transcription factor CDX2.

Authors:  O Houghton; L E Connolly; W G McCluggage
Journal:  Histopathology       Date:  2008-08       Impact factor: 5.087

9.  No association between gastric fundic gland polyps and gastrointestinal neoplasia in a study of over 100,000 patients.

Authors:  Robert M Genta; Christopher M Schuler; Cristian I Robiou; Richard H Lash
Journal:  Clin Gastroenterol Hepatol       Date:  2009-05-22       Impact factor: 11.382

10.  Immunohistochemical characterization of squamous differentiation and morular metaplasia in uterine endometrioid adenocarcinoma.

Authors:  Luis Z Blanco; Dawn E Heagley; John C Lee; Allen M Gown; Paolo Gattuso; Jacob Rotmensch; Alfred Guirguis; Summer Dewdney; Pincas Bitterman
Journal:  Int J Gynecol Pathol       Date:  2013-05       Impact factor: 2.762
View more
  1 in total

1.  Successful treatment of proton pump inhibitor induced sporadic fundic gland polyps with an argon plasma coagulator in a patient with polycythaemia vera.

Authors:  Kazuya Kato; Yoshiaki Iwasaki; Masahiko Taniguchi; Kazuhiko Onodera; Takako Kawakami; Minoru Matsuda; Mineko Higuchi; Kimitaka Kato; Yurina Kato; Susumu Tamakawa; Hiroyuki Furukawa
Journal:  Int J Surg Case Rep       Date:  2017-02-24
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.