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Literature DB >> 24694724

Mechanisms and dynamics of nuclear lamina-genome interactions.

Abstract

The nuclear lamina (NL) interacts with the genomic DNA and is thought to influence chromosome organization and gene expression. Both DNA sequences and histone modifications are important for NL tethering of the genomic DNA. These interactions are dynamic in individual cells and can change during differentiation and development. Evidence is accumulating that the NL contributes to the repression of transcription. Advances in mapping, genome-editing and microscopy techniques are increasing our understanding of the molecular mechanisms involved in NL-genome interactions.

Mesh：

Substances：
Chromatin

Year: 2014 PMID： 24694724 DOI： 10.1016/j.ceb.2014.03.003

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

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Cited

64 in total

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Authors: Deborah R Winter; Steffen Jung; Ido Amit
Journal: Nat Rev Immunol Date: 2015-08-14 Impact factor: 53.106

Review 2. The interplay of epigenetic marks during stem cell differentiation and development.

Authors: Yaser Atlasi; Hendrik G Stunnenberg
Journal: Nat Rev Genet Date: 2017-08-14 Impact factor: 53.242

Review 3. Beyond Tethering and the LEM domain: MSCellaneous functions of the inner nuclear membrane Lem2.

Authors: Sigurd Braun; Ramón Ramos Barrales
Journal: Nucleus Date: 2016-10-31 Impact factor: 4.197

Review 4. Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression.

Authors: Jesse M Engreitz; Noah Ollikainen; Mitchell Guttman
Journal: Nat Rev Mol Cell Biol Date: 2016-10-26 Impact factor: 94.444

Review 5. The Nucleoskeleton.

Authors: Stephen A Adam
Journal: Cold Spring Harb Perspect Biol Date: 2017-02-01 Impact factor: 10.005

6. Suppression of myopathic lamin mutations by muscle-specific activation of AMPK and modulation of downstream signaling.

Authors: Sahaana Chandran; Jennifer A Suggs; Bingyan J Wang; Andrew Han; Shruti Bhide; Diane E Cryderman; Steven A Moore; Sanford I Bernstein; Lori L Wallrath; Girish C Melkani
Journal: Hum Mol Genet Date: 2019-02-01 Impact factor: 6.150

Mechanisms and dynamics of nuclear lamina-genome interactions.

Review 1. Making the case for chromatin profiling: a new tool to investigate the immune-regulatory landscape.

Review 2. The interplay of epigenetic marks during stem cell differentiation and development.

Review 3. Beyond Tethering and the LEM domain: MSCellaneous functions of the inner nuclear membrane Lem2.

Review 4. Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression.

Review 5. The Nucleoskeleton.

6. Suppression of myopathic lamin mutations by muscle-specific activation of AMPK and modulation of downstream signaling.

7. Chromatin organization as an indicator of glucocorticoid induced natural killer cell dysfunction.

8. Role of Inner Nuclear Membrane Protein Complex Lem2-Nur1 in Heterochromatic Gene Silencing.

Review 9. Mixing and matching nuclear envelope remodeling and spindle assembly strategies in the evolution of mitosis.

10. The molecular basis of emerin-emerin and emerin-BAF interactions.