Literature DB >> 24693892

Thyroid hormone inactivation in gastrointestinal stromal tumors.

Michelle A Maynard1, Adrian Marino-Enriquez, Jonathan A Fletcher, David M Dorfman, Chandrajit P Raut, Leila Yassa, Cuicui Guo, Yuexiang Wang, Clara Dorfman, Henry A Feldman, Mary C Frates, Huaidong Song, Rebecca H Jugo, Takahiro Taguchi, Jerome M Hershman, P Reed Larsen, Stephen A Huang.   

Abstract

Gastrointestinal stromal tumors (GISTs) are resistant to traditional chemotherapy but are responsive to the tyrosine kinase inhibitors imatinib and sunitinib. The use of these agents has improved the outcome for patients but is associated with adverse effects, including hypothyroidism. Multiple mechanisms of this effect have been proposed, including decreased iodine organification and glandular capillary regression. Here we report the finding of consumptive hypothyroidism caused by marked overexpression of the thyroid hormone-inactivating enzyme type 3 iodothyronine deiodinase (D3) within the tumor. Affected patients warrant increased monitoring and may require supernormal thyroid hormone supplementation.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24693892      PMCID： PMC4186889          DOI： 10.1056/NEJMoa1308893

Source DB:  PubMed          Journal:  N Engl J Med        ISSN： 0028-4793            Impact factor:   91.245


  25 in total

1.  Conventional and molecular cytogenetic characterization of a new human cell line, GIST-T1, established from gastrointestinal stromal tumor.

Authors:  Takahiro Taguchi; Hiroshi Sonobe; Shin-ichi Toyonaga; Ichiro Yamasaki; Taro Shuin; Atsushi Takano; Keijiro Araki; Kunihiro Akimaru; Kazunari Yuri
Journal:  Lab Invest       Date:  2002-05       Impact factor: 5.662

2.  Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium.

Authors:  Stephen A Huang; David M Dorfman; David R Genest; Domenico Salvatore; P Reed Larsen
Journal:  J Clin Endocrinol Metab       Date:  2003-03       Impact factor: 5.958

Review 3.  Thyroid dysfunction from antineoplastic agents.

Authors:  Ole-Petter Riksfjord Hamnvik; P Reed Larsen; Ellen Marqusee
Journal:  J Natl Cancer Inst       Date:  2011-10-18       Impact factor: 13.506

4.  Removal of serum factors by charcoal treatment promotes adipogenesis via a MAPK-dependent pathway.

Authors:  Z C Dang; C W G M Lowik
Journal:  Mol Cell Biochem       Date:  2005-01       Impact factor: 3.396

5.  Parameters of thyroid function in serum of 16 selected vertebrate species: a study of PBI, serum T4, free T4, and the pattern of T4 and T3 binding to serum proteins.

Authors:  S Refetoff; N I Robin; V S Fang
Journal:  Endocrinology       Date:  1970-04       Impact factor: 4.736

6.  Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.

Authors:  S Hirota; K Isozaki; Y Moriyama; K Hashimoto; T Nishida; S Ishiguro; K Kawano; M Hanada; A Kurata; M Takeda; G Muhammad Tunio; Y Matsuzawa; Y Kanakura; Y Shinomura; Y Kitamura
Journal:  Science       Date:  1998-01-23       Impact factor: 47.728

7.  Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III).

Authors:  Joseph G Hollowell; Norman W Staehling; W Dana Flanders; W Harry Hannon; Elaine W Gunter; Carole A Spencer; Lewis E Braverman
Journal:  J Clin Endocrinol Metab       Date:  2002-02       Impact factor: 5.958

8.  Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles.

Authors:  Subbaya Subramanian; Robert B West; Christopher L Corless; Wenbin Ou; Brian P Rubin; Kent-Man Chu; Suet Yi Leung; Siu Tsan Yuen; Shirley Zhu; Tina Hernandez-Boussard; Kelli Montgomery; Torsten O Nielsen; Rajiv M Patel; John R Goldblum; Michael C Heinrich; Jonathan A Fletcher; Matt van de Rijn
Journal:  Oncogene       Date:  2004-10-14       Impact factor: 9.867

9.  A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase.

Authors:  Stephen A Huang; Stephanie A Fish; David M Dorfman; Domenico Salvatore; Harry P W Kozakewich; Susan J Mandel; P Reed Larsen
Journal:  J Clin Endocrinol Metab       Date:  2002-10       Impact factor: 5.958

10.  PDGFRA activating mutations in gastrointestinal stromal tumors.

Authors:  Michael C Heinrich; Christopher L Corless; Anette Duensing; Laura McGreevey; Chang-Jie Chen; Nora Joseph; Samuel Singer; Diana J Griffith; Andrea Haley; Ajia Town; George D Demetri; Christopher D M Fletcher; Jonathan A Fletcher
Journal:  Science       Date:  2003-01-09       Impact factor: 47.728
View more
  16 in total

1.  Decade in review-thyroid disease: The endocrinology of thyroid disease from 2005 to 2015.

Authors:  P Reed Larsen
Journal:  Nat Rev Endocrinol       Date:  2015-10-06       Impact factor: 43.330

2.  Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement.

Authors:  Jacqueline Jonklaas; Antonio C Bianco; Andrew J Bauer; Kenneth D Burman; Anne R Cappola; Francesco S Celi; David S Cooper; Brian W Kim; Robin P Peeters; M Sara Rosenthal; Anna M Sawka
Journal:  Thyroid       Date:  2014-12       Impact factor: 6.568

Review 3.  VEGF-targeted cancer therapeutics-paradoxical effects in endocrine organs.

Authors:  Yihai Cao
Journal:  Nat Rev Endocrinol       Date:  2014-07-22       Impact factor: 43.330

Review 4.  Hypothyroidism.

Authors:  Layal Chaker; Salman Razvi; Isabela M Bensenor; Fereidoun Azizi; Elizabeth N Pearce; Robin P Peeters
Journal:  Nat Rev Dis Primers       Date:  2022-05-19       Impact factor: 52.329

5.  Optimal Thyroid Hormone Replacement Dose in Immune Checkpoint Inhibitor-Associated Hypothyroidism Is Distinct from Hashimoto's Thyroiditis.

Authors:  Tina Mosaferi; Karen Tsai; Samantha Sovich; Holly Wilhalme; Nikhita Kathuria-Prakash; Stephanie S Praw; Alexandra Drakaki; Trevor E Angell; Melissa G Lechner
Journal:  Thyroid       Date:  2022-03-31       Impact factor: 6.506

6.  Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size.

Authors:  Cuicui Guo; Xia Chen; Huaidong Song; Michelle A Maynard; Yi Zhou; Alexei V Lobanov; Vadim N Gladyshev; Jared J Ganis; David Wiley; Rebecca H Jugo; Nicholas Y Lee; Luciana A Castroneves; Leonard I Zon; Thomas S Scanlan; Henry A Feldman; Stephen A Huang
Journal:  Endocrinology       Date:  2014-07-08       Impact factor: 4.736

7.  Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis.

Authors:  Luciana A Castroneves; Rebecca H Jugo; Michelle A Maynard; Jennifer S Lee; Ari J Wassner; David Dorfman; Roderick T Bronson; Chinweike Ukomadu; Agoston T Agoston; Lai Ding; Cristina Luongo; Cuicui Guo; Huaidong Song; Valeriy Demchev; Nicholas Y Lee; Henry A Feldman; Kristen R Vella; Roy W Peake; Christina Hartigan; Mark D Kellogg; Anal Desai; Domenico Salvatore; Monica Dentice; Stephen A Huang
Journal:  Endocrinology       Date:  2014-07-08       Impact factor: 4.736

8.  Consumptive Hypothyroidism: Case Report of Hepatic Hemangioendotheliomas Successfully Treated with Vincristine and Systematic Review of the Syndrome.

Authors:  Marina Weber Pasa; Rafael Selbach Scheffel; André Borsatto Zanella; Ana Luiza Maia; José Miguel Dora
Journal:  Eur Thyroid J       Date:  2017-10-13

Review 9.  Defending plasma T3 is a biological priority.

Authors:  Sherine M Abdalla; Antonio C Bianco
Journal:  Clin Endocrinol (Oxf)       Date:  2014-08-07       Impact factor: 3.478

10.  Iodide transport: implications for health and disease.

Authors:  Liuska Pesce; Peter Kopp
Journal:  Int J Pediatr Endocrinol       Date:  2014-05-30
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.