Literature DB >> 24692555

RNA and β-hemolysin of group B Streptococcus induce interleukin-1β (IL-1β) by activating NLRP3 inflammasomes in mouse macrophages.

Rahul Gupta1, Shubhendu Ghosh1, Brian Monks1, Rosane B DeOliveira1, Te-Chen Tzeng1, Parisa Kalantari1, Anubhab Nandy1, Bornali Bhattacharjee1, Jennie Chan1, Fabianno Ferreira2, Vijay Rathinam1, Shruti Sharma1, Egil Lien1, Neal Silverman1, Katherine Fitzgerald1, Arnaud Firon3, Patrick Trieu-Cuot3, Philipp Henneke4, Douglas T Golenbock5.   

Abstract

The inflammatory cytokine IL-1β is critical for host responses against many human pathogens. Here, we define Group B Streptococcus (GBS)-mediated activation of the Nod-like receptor-P3 (NLRP3) inflammasome in macrophages. NLRP3 activation requires GBS expression of the cytolytic toxin, β-hemolysin, lysosomal acidification, and leakage. These processes allow the interaction of GBS RNA with cytosolic NLRP3. The present study supports a model in which GBS RNA, along with lysosomal components including cathepsins, leaks out of lysosomes and interacts with NLRP3 to induce IL-1β production.
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  Cell Signaling; Immunology; Innate Immunity; Interleukin; RNA

Mesh：

Substances：

Year:  2014        PMID： 24692555      PMCID： PMC4022842          DOI： 10.1074/jbc.C114.548982

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  17 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-09       Impact factor: 11.205

5.  Activation of the NLRP3 inflammasome by group B streptococci.

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Authors:  Philipp Henneke; Osamu Takeuchi; Richard Malley; Egil Lien; Robin R Ingalls; Mason W Freeman; Tanya Mayadas; Victor Nizet; Shizuo Akira; Dennis L Kasper; Douglas T Golenbock
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  37 in total

Review 1.  Molecular mechanisms regulating NLRP3 inflammasome activation.

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Journal:  Immunol Rev       Date:  2015-05       Impact factor: 12.988

3.  A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome.

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4.  Diminished Capsule Exacerbates Virulence, Blood-Brain Barrier Penetration, Intracellular Persistence, and Antibiotic Evasion of Hyperhemolytic Group B Streptococci.

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Review 5.  Immunity to uropathogens: the emerging roles of inflammasomes.

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Review 7.  The Emerging Role of Inflammasomes as Central Mediators in Inflammatory Bladder Pathology.

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Review 8.  Intrinsic Maturational Neonatal Immune Deficiencies and Susceptibility to Group B Streptococcus Infection.

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9.  Molecular Characterization of Nonhemolytic and Nonpigmented Group B Streptococci Responsible for Human Invasive Infections.

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10.  A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection.

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