BACKGROUND: In the present study, the influence of cytokines on 1-year recovery in lumbar radicular pain was examined. METHODS: In total, 110 patients with symptomatic lumbar disc herniation were followed for 1 year. Uni- and multivariate linear regression was used to assess the influence of interleukin (IL)-6, IL-8, disc degeneration and endplate changes (Modic changes) on the changes in the Oswestry Disability Index (ODI change; primary outcome) and visual analogue scale (VAS) for low back pain (LBP) and leg pain (secondary outcomes). RESULTS: Less favourable ODI outcome correlated with higher serum IL-6 levels (B = -3.41, 95% CI -5.52 to -1.30, p = 0.002), non-surgical treatment (B = -7.03, 95% CI 1.21 to 12.84, p = 0.018), higher baseline back pain intensity (B = -2.28, 95% CI -3.21 to -1.35, p < 0.001) and low educational level (B = -5.57, 95% CI 0.66 to 10.47, p = 0.027). High VAS for LBP and leg pain at 1 year was associated with high levels of serum IL-6, higher back pain intensity and longer duration of lumbar radicular pain at baseline. CONCLUSIONS: High serum IL-6 levels, but not disc degeneration or Modic changes, were associated with less favourable recovery in patients with lumbar radicular pain. Intense initial back pain, non-surgical treatment, lower educational level and longer duration of radicular pain before treatment also correlated with a slower recovery the first year after disc herniation.
BACKGROUND: In the present study, the influence of cytokines on 1-year recovery in lumbar radicular pain was examined. METHODS: In total, 110 patients with symptomatic lumbar disc herniation were followed for 1 year. Uni- and multivariate linear regression was used to assess the influence of interleukin (IL)-6, IL-8, disc degeneration and endplate changes (Modic changes) on the changes in the Oswestry Disability Index (ODI change; primary outcome) and visual analogue scale (VAS) for low back pain (LBP) and leg pain (secondary outcomes). RESULTS: Less favourable ODI outcome correlated with higher serum IL-6 levels (B = -3.41, 95% CI -5.52 to -1.30, p = 0.002), non-surgical treatment (B = -7.03, 95% CI 1.21 to 12.84, p = 0.018), higher baseline back pain intensity (B = -2.28, 95% CI -3.21 to -1.35, p < 0.001) and low educational level (B = -5.57, 95% CI 0.66 to 10.47, p = 0.027). High VAS for LBP and leg pain at 1 year was associated with high levels of serum IL-6, higher back pain intensity and longer duration of lumbar radicular pain at baseline. CONCLUSIONS: High serum IL-6 levels, but not disc degeneration or Modic changes, were associated with less favourable recovery in patients with lumbar radicular pain. Intense initial back pain, non-surgical treatment, lower educational level and longer duration of radicular pain before treatment also correlated with a slower recovery the first year after disc herniation.
Authors: Aysha N Khan; Hayley E Jacobsen; Jansher Khan; Christopher G Filippi; Mitchell Levine; Ronald A Lehman; K Daniel Riew; Lawrence G Lenke; Nadeen O Chahine Journal: Ann N Y Acad Sci Date: 2017-12 Impact factor: 5.691
Authors: Brent T Mausbach; Gabrielle Decastro; Carlos Vara-Garcia; Taylor C Bos; Roland von Känel; Michael G Ziegler; Joel E Dimsdale; Matthew A Allison; Paul J Mills; Thomas L Patterson; Sonia Ancoli-Israel; Christopher Pruitt; Igor Grant Journal: Psychosom Med Date: 2019-09 Impact factor: 3.864
Authors: Paul J Austin; Annika M Berglund; Sherman Siu; Nathan T Fiore; Michelle B Gerke-Duncan; Suzanne L Ollerenshaw; Sarah-Jane Leigh; Priya A Kunjan; James W M Kang; Kevin A Keay Journal: J Neuroinflammation Date: 2015-05-20 Impact factor: 8.322
Authors: K T Weber; Shina Satoh; D Olivier Alipui; Justin Virojanapa; Mitchell Levine; Cristina Sison; Shaheda Quraishi; Ona Bloom; Nadeen O Chahine Journal: Immunol Res Date: 2015-12 Impact factor: 2.829
Authors: Kathryn T Weber; D Olivier Alipui; Cristina P Sison; Ona Bloom; Shaheda Quraishi; M Chris Overby; Mitchell Levine; Nadeen O Chahine Journal: Arthritis Res Ther Date: 2016-01-07 Impact factor: 5.156