Literature DB >> 24691478

Harnessing FOXP3+ regulatory T cells for transplantation tolerance.

Herman Waldmann, Robert Hilbrands, Duncan Howie, Stephen Cobbold.   

Abstract

Early demonstrations that mice could be tolerized to transplanted tissues with short courses of immunosuppressive therapy and that with regard to tolerance to self, CD4+FOXP3+ regulatory T cells (Tregs) appeared to play a critical role, have catalyzed strategies to harness FOXP3-dependent processes to control rejection in human transplantation. This review seeks to examine the scientific underpinning for this new approach to finesse immunosuppression.

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Year:  2014        PMID： 24691478      PMCID： PMC3973097          DOI： 10.1172/JCI67226

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  107 in total

1.  Homeostatic proliferation is a barrier to transplantation tolerance.

Authors:  Zihao Wu; Steven J Bensinger; Jidong Zhang; Chuangqi Chen; Xueli Yuan; Xiaolun Huang; James F Markmann; Alireza Kassaee; Bruce R Rosengard; Wayne W Hancock; Mohamed H Sayegh; Laurence A Turka
Journal:  Nat Med       Date:  2003-11-30       Impact factor: 53.440

2.  Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity.

Authors:  Noriko Komatsu; Maria Encarnita Mariotti-Ferrandiz; Ying Wang; Bernard Malissen; Herman Waldmann; Shohei Hori
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-27       Impact factor: 11.205

3.  T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.

Authors:  Naganari Ohkura; Masahide Hamaguchi; Hiromasa Morikawa; Kyoko Sugimura; Atsushi Tanaka; Yoshinaga Ito; Motonao Osaki; Yoshiaki Tanaka; Riu Yamashita; Naoko Nakano; Jochen Huehn; Hans Joerg Fehling; Tim Sparwasser; Kenta Nakai; Shimon Sakaguchi
Journal:  Immunity       Date:  2012-11-01       Impact factor: 31.745

4.  Induction of tolerance by monoclonal antibody therapy.

Authors:  R J Benjamin; H Waldmann
Journal:  Nature       Date:  1986 Apr 3-9       Impact factor: 49.962

5.  Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity.

Authors:  Keli L Hippen; Sarah C Merkel; Dawn K Schirm; Christine M Sieben; Darin Sumstad; Diane M Kadidlo; David H McKenna; Jonathan S Bromberg; Bruce L Levine; James L Riley; Carl H June; Phillip Scheinberg; Daniel C Douek; Jeffrey S Miller; John E Wagner; Bruce R Blazar
Journal:  Sci Transl Med       Date:  2011-05-18       Impact factor: 17.956

6.  Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

Authors:  Takahisa Miyao; Stefan Floess; Ruka Setoguchi; Hervé Luche; Hans Joerg Fehling; Herman Waldmann; Jochen Huehn; Shohei Hori
Journal:  Immunity       Date:  2012-02-09       Impact factor: 31.745

7.  Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells.

Authors:  Pervinder Sagoo; Niwa Ali; Garima Garg; Frank O Nestle; Robert I Lechler; Giovanna Lombardi
Journal:  Sci Transl Med       Date:  2011-05-18       Impact factor: 17.956

8.  Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation.

Authors:  A L Putnam; N Safinia; A Medvec; M Laszkowska; M Wray; M A Mintz; E Trotta; G L Szot; W Liu; A Lares; K Lee; A Laing; R I Lechler; J L Riley; J A Bluestone; G Lombardi; Q Tang
Journal:  Am J Transplant       Date:  2013-09-18       Impact factor: 8.086

9.  Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells.

Authors:  B M Hall; M E Jelbart; K E Gurley; S E Dorsch
Journal:  J Exp Med       Date:  1985-11-01       Impact factor: 14.307

10.  Biomarkers of transplantation tolerance: more hopeful than helpful?

Authors:  Stephen P Cobbold; Elizabeth Adams; Herman Waldmann
Journal:  Front Immunol       Date:  2011-04-06       Impact factor: 7.561
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  24 in total

Review 1.  Mesenchymal stromal cells in renal transplantation: opportunities and challenges.

Authors:  Federica Casiraghi; Norberto Perico; Monica Cortinovis; Giuseppe Remuzzi
Journal:  Nat Rev Nephrol       Date:  2016-02-08       Impact factor: 28.314

2.  The cAMP-Adenosine Feedback Loop Maintains the Suppressive Function of Regulatory T Cells.

Authors:  Wenru Su; Xiaoqing Chen; Wenjie Zhu; Jianfeng Yu; Weihua Li; Yingqi Li; Zhuang Li; Nancy Olsen; Dan Liang; Song Guo Zheng
Journal:  J Immunol       Date:  2019-08-16       Impact factor: 5.422

Review 3.  Impact of infection on transplantation tolerance.

Authors:  Shuangjin Yu; Chang Su; Xunrong Luo
Journal:  Immunol Rev       Date:  2019-09-19       Impact factor: 12.988

4.  The contribution of B cells to transplantation tolerance.

Authors:  Luis Graca
Journal:  J Clin Invest       Date:  2020-07-01       Impact factor: 14.808

Review 5.  Murine models of transplantation tolerance through mixed chimerism: advances and roadblocks.

Authors:  B Mahr; T Wekerle
Journal:  Clin Exp Immunol       Date:  2017-05-22       Impact factor: 4.330

Review 6.  Interpretation of transplant biopsies and immune responses following Treg cell therapy.

Authors:  Qizhi Tang; Sang-Mo Kang
Journal:  Curr Opin Organ Transplant       Date:  2014-12       Impact factor: 2.640

7.  Driving allotolerance: CAR-expressing Tregs for tolerance induction in organ and stem cell transplantation.

Authors:  Matthias Edinger
Journal:  J Clin Invest       Date:  2016-03-21       Impact factor: 14.808

8.  Type 1 diabetes immunotherapy using polyclonal regulatory T cells.

Authors:  Jeffrey A Bluestone; Jane H Buckner; Mark Fitch; Stephen E Gitelman; Shipra Gupta; Marc K Hellerstein; Kevan C Herold; Angela Lares; Michael R Lee; Kelvin Li; Weihong Liu; S Alice Long; Lisa M Masiello; Vinh Nguyen; Amy L Putnam; Mary Rieck; Peter H Sayre; Qizhi Tang
Journal:  Sci Transl Med       Date:  2015-11-25       Impact factor: 17.956

Review 9.  Organ-specific and memory treg cells: specificity, development, function, and maintenance.

Authors:  Iris K Gratz; Daniel J Campbell
Journal:  Front Immunol       Date:  2014-07-15       Impact factor: 7.561

Review 10.  Regulatory T cell-derived exosomes: possible therapeutic and diagnostic tools in transplantation.

Authors:  Akansha Agarwal; Giorgia Fanelli; Marilena Letizia; Sim Lai Tung; Dominic Boardman; Robert Lechler; Giovanna Lombardi; Lesley A Smyth
Journal:  Front Immunol       Date:  2014-11-05       Impact factor: 7.561
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