Kyungmi Kim1, Wook-Jong Kim1, Dae-Kee Choi1, Yoon Kyung Lee2, In-Cheol Choi1, Ji-Yeon Sim3. 1. Department of Anaesthesia and Pain Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Republic of Korea. 2. Department of Anaesthesia and Pain Medicine, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Republic of Korea. 3. Department of Anaesthesia and Pain Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Republic of Korea jysim@amc.seoul.kr.
Abstract
OBJECTIVE: The efficacy and side-effects of nefopam were prospectively compared with those of fentanyl for patient-controlled analgesia (PCA) following cardiac surgery. METHODS:Patients scheduled to undergo cardiac surgery were randomly assigned between three PCA groups (nefopam, fentanyl or nefopam + fentanyl). Pain was assessed at rest and during movement at 12, 24, 36, 48 and 72 h after surgery using a visual analogue scale (VAS). Total infused PCA volume, number of rescue drug injections, duration of intubation and length of stay in the intensive care unit were recorded. The incidence of adverse effects was noted at 48 h postoperatively. RESULTS: There were no significant between-group differences in VAS score, total PCA infusion volume or number of rescue injections (n = 92 per group). Nausea was significantly more common in the fentanyl group compared with both other groups. CONCLUSIONS:PCA with nefopam alone provides suitable postoperative analgesia after cardiac surgery.
RCT Entities:
OBJECTIVE: The efficacy and side-effects of nefopam were prospectively compared with those of fentanyl for patient-controlled analgesia (PCA) following cardiac surgery. METHODS:Patients scheduled to undergo cardiac surgery were randomly assigned between three PCA groups (nefopam, fentanyl or nefopam + fentanyl). Pain was assessed at rest and during movement at 12, 24, 36, 48 and 72 h after surgery using a visual analogue scale (VAS). Total infused PCA volume, number of rescue drug injections, duration of intubation and length of stay in the intensive care unit were recorded. The incidence of adverse effects was noted at 48 h postoperatively. RESULTS: There were no significant between-group differences in VAS score, total PCA infusion volume or number of rescue injections (n = 92 per group). Nausea was significantly more common in the fentanyl group compared with both other groups. CONCLUSIONS: PCA with nefopam alone provides suitable postoperative analgesia after cardiac surgery.
Authors: Kathleen E Wheeler; Ryan Grilli; John E Centofanti; Janet Martin; Celine Gelinas; Paul M Szumita; John W Devlin; Gerald Chanques; Waleed Alhazzani; Yoanna Skrobik; Michelle E Kho; Mark E Nunnally; Andre Gagarine; Begum A Ergan; Shannon Fernando; Carrie Price; John Lewin; Bram Rochwerg Journal: Crit Care Explor Date: 2020-07-06