Johannes Ott1, Christine Kurz1, Ronald Braun1, Regina Promberger2, Rudolf Seemann3, Elisabeth Vytiska-Binstorfer1, Katharina Walch4. 1. Department of Gynecological Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria. 2. Department of Surgery, Medical University of Vienna, Vienna, Austria. 3. Department of Craniomaxillofacial and Oral Surgery, Medical University of Vienna, Vienna, Austria. 4. Department of Gynecological Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria. Electronic address: katharina.walch@meduniwien.ac.at.
Abstract
OBJECTIVE: A possible correlation between uterine leiomyoma and thyroid disease was reported decades ago. We aimed to evaluate the possible associations between the presence of uterine leiomyomas and (i) the presence of overt hypothyroidism, (ii) the level of anti-thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab), and (iii) thyroid stimulating hormone (TSH) levels. STUDY DESIGN: In a retrospective study, all 215 sterile women who underwent reproductive surgery (hysteroscopy and laparoscopy/laparotomy) at our department from January 2007 to January 2011 were included. All leiomyomas suspected on gynecologic ultrasound were verified during surgery. As risk factors for uterine leiomyomas, thyroid parameters, age, African heritage, age at menarche, parity, and body mass index were included. RESULTS: One or more uterine leiomyomas were found in 51 cases (23.7%). After multivariate analysis, three parameters remained significant, with African heritage the most important (odds ratio, OR, 27.80), followed by overt hypothyroidism (OR 3.10) and increasing age (OR 1.23). Larger leiomyomas were found in women with overt hypothyroidism than in those without overt hypothyroidism (median, 70 mm; range, 5-88 vs. median, 30 mm; range, 2-93, respectively; p=0.007). CONCLUSIONS: Overt hypothyroidism, but not autoantibodies against the thyroid gland, was associated with the presence of uterine leiomyoma in our study.
OBJECTIVE: A possible correlation between uterine leiomyoma and thyroid disease was reported decades ago. We aimed to evaluate the possible associations between the presence of uterine leiomyomas and (i) the presence of overt hypothyroidism, (ii) the level of anti-thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab), and (iii) thyroid stimulating hormone (TSH) levels. STUDY DESIGN: In a retrospective study, all 215 sterile women who underwent reproductive surgery (hysteroscopy and laparoscopy/laparotomy) at our department from January 2007 to January 2011 were included. All leiomyomas suspected on gynecologic ultrasound were verified during surgery. As risk factors for uterine leiomyomas, thyroid parameters, age, African heritage, age at menarche, parity, and body mass index were included. RESULTS: One or more uterine leiomyomas were found in 51 cases (23.7%). After multivariate analysis, three parameters remained significant, with African heritage the most important (odds ratio, OR, 27.80), followed by overt hypothyroidism (OR 3.10) and increasing age (OR 1.23). Larger leiomyomas were found in women with overt hypothyroidism than in those without overt hypothyroidism (median, 70 mm; range, 5-88 vs. median, 30 mm; range, 2-93, respectively; p=0.007). CONCLUSIONS: Overt hypothyroidism, but not autoantibodies against the thyroid gland, was associated with the presence of uterine leiomyoma in our study.
Authors: Marina Kvaskoff; Fan Mu; Kathryn L Terry; Holly R Harris; Elizabeth M Poole; Leslie Farland; Stacey A Missmer Journal: Hum Reprod Update Date: 2015-03-11 Impact factor: 15.610
Authors: Laura A Schieve; Carolyn Drews-Botsch; Shericka Harris; Craig Newschaffer; Julie Daniels; Carolyn DiGuiseppi; Lisa A Croen; Gayle C Windham Journal: J Autism Dev Disord Date: 2017-12
Authors: Jacklyn N Hellwege; Janina M Jeff; Lauren A Wise; C Scott Gallagher; Melissa Wellons; Katherine E Hartmann; Sarah F Jones; Eric S Torstenson; Scott Dickinson; Edward A Ruiz-Narváez; Nadin Rohland; Alexander Allen; David Reich; Arti Tandon; Bogdan Pasaniuc; Nicholas Mancuso; Hae Kyung Im; David A Hinds; Julie R Palmer; Lynn Rosenberg; Joshua C Denny; Dan M Roden; Elizabeth A Stewart; Cynthia C Morton; Eimear E Kenny; Todd L Edwards; Digna R Velez Edwards Journal: Hum Genet Date: 2017-08-23 Impact factor: 5.881
Authors: Hanna-Riikka Heinonen; Annukka Pasanen; Oskari Heikinheimo; Tomas Tanskanen; Kimmo Palin; Jaana Tolvanen; Pia Vahteristo; Jari Sjöberg; Esa Pitkänen; Ralf Bützow; Netta Mäkinen; Lauri A Aaltonen Journal: Sci Rep Date: 2017-04-21 Impact factor: 4.379