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Literature DB >> 24689484

The first CNS-active carborane: A novel P2X7 receptor antagonist with antidepressant activity.

Shane M Wilkinson¹, Hendra Gunosewoyo, Melissa L Barron, Aurelie Boucher, Michelle McDonnell, Peter Turner, Daniel E Morrison, Maxwell R Bennett, Iain S McGregor, Louis M Rendina, Michael Kassiou.

Abstract

Relative to other polycyclic frameworks (1-3), a carborane cage (4 and Cs·5) exerts a significant biological effect as an inhibitor of the purinergic P2X7 receptor (P2X7R) which allows one to target depression in vivo and thus demonstrate, for the first time, that a carborane has the capacity to modify CNS activity.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2014 PMID： 24689484 PMCID： PMC4030799 DOI： 10.1021/cn500054n

Source DB: PubMed Journal: ACS Chem Neurosci ISSN： 1948-7193 Impact factor: 4.418

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