AIM: To investigate the relationship between natural killer (NK) cell phenotype and recurrent miscarriage (RM). METHODS: We studied killer cell immunoglobulin-like receptor (KIR) expression on decidual NK cells in women with RM. RESULTS: The expression of KIR2DL1/S1 on CD56(+) CD16(-) NK cells in the deciduas of these women was significantly lower than in that of control subjects (P = 0.026). There was a significant decline in the frequency of CD56(+) CD16(-) NK cells staining for KIR2DL1/S1 and KIR2DL2/S2/L3 throughout the first trimester in patients (P < 0.05). Furthermore, by stratification of the women in three groups according to gestational stage, it was found that KIR2DL1/S1 expressing NK cells were significantly decreased in all groups, especially around gestational days 50-70 (P = 0.010). CONCLUSION: This is the first report to demonstrate that RM is associated with a decline in the frequency of decidual NK cells expressing KIR specific for human leukocyte antigen (HLA)-C, and in which gestational stage was considered. The results suggest that KIR phenotype contributes to the pathogenesis of the disease, and that assessment of KIR may serve as a diagnostic tool.
AIM: To investigate the relationship between natural killer (NK) cell phenotype and recurrent miscarriage (RM). METHODS: We studied killer cell immunoglobulin-like receptor (KIR) expression on decidual NK cells in women with RM. RESULTS: The expression of KIR2DL1/S1 on CD56(+) CD16(-) NK cells in the deciduas of these women was significantly lower than in that of control subjects (P = 0.026). There was a significant decline in the frequency of CD56(+) CD16(-) NK cells staining for KIR2DL1/S1 and KIR2DL2/S2/L3 throughout the first trimester in patients (P < 0.05). Furthermore, by stratification of the women in three groups according to gestational stage, it was found that KIR2DL1/S1 expressing NK cells were significantly decreased in all groups, especially around gestational days 50-70 (P = 0.010). CONCLUSION: This is the first report to demonstrate that RM is associated with a decline in the frequency of decidual NK cells expressing KIR specific for humanleukocyte antigen (HLA)-C, and in which gestational stage was considered. The results suggest that KIR phenotype contributes to the pathogenesis of the disease, and that assessment of KIR may serve as a diagnostic tool.
Authors: L Zhu; M Aly; H Wang; H Karakizlis; R Weimer; C Morath; R J Kuon; B Toth; N Ekpoom; G Opelz; V Daniel Journal: Clin Exp Immunol Date: 2018-05-31 Impact factor: 4.330
Authors: Ee Von Woon; Orene Greer; Nishel Shah; Dimitrios Nikolaou; Mark Johnson; Victoria Male Journal: Hum Reprod Update Date: 2022-06-30 Impact factor: 17.179
Authors: Ana Esteve-Solé; Yiyi Luo; Alexandru Vlagea; Ángela Deyà-Martínez; Jordi Yagüe; Ana María Plaza-Martín; Manel Juan; Laia Alsina Journal: Int J Mol Sci Date: 2018-07-19 Impact factor: 5.923
Authors: Monika Kniotek; Aleksander Roszczyk; Michał Zych; Monika Szafarowska; Małgorzata Jerzak Journal: Biomed Res Int Date: 2021-05-04 Impact factor: 3.411