Literature DB >> 24688110

Primary thrombocytosis in children.

Nicole Kucine1, Katherine M Chastain, Michelle B Mahler, James B Bussel.   

Abstract

Myeloproliferative neoplasms are uncommon disorders in children, for which we have limited understanding of the pathogenesis and optimal management. JAK2 and MPL mutations, while common drivers of myeloproliferative neoplasms in adult patients, are not clearly linked to pediatric disease. Management and clinical outcomes in adults have been well delineated with defined recommendations for risk stratification and treatment. This is not the case for pediatric patients, for whom there is neither a standard approach to workup nor any consensus regarding management. This review will discuss thrombocytosis in children, including causes of thrombocytosis in children, the limited knowledge we have regarding pediatric primary thrombocytosis, and our thoughts on potential risk stratification and management, and future questions to be answered by laboratory research and collaborative clinical study.

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Mesh：

Year:  2014        PMID： 24688110      PMCID： PMC3971071          DOI： 10.3324/haematol.2013.092684

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  90 in total

1.  Amino acid sequence homology of thrombopoietin and erythropoietin may explain thrombocytosis in children with iron deficiency anemia.

Authors:  Ernest Bilic; Ervina Bilic
Journal:  J Pediatr Hematol Oncol       Date:  2003-08       Impact factor: 1.289

2.  A basic classification and a comprehensive examination of pediatric myeloproliferative syndromes.

Authors:  Adam Gassas; John J Doyle; Sheila Weitzman; Melvin H Freedman; Johann K Hitzler; Anjali Sharathkumar; Yigal Dror
Journal:  J Pediatr Hematol Oncol       Date:  2005-04       Impact factor: 1.289

3.  Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.

Authors:  Ross L Levine; Martha Wadleigh; Jan Cools; Benjamin L Ebert; Gerlinde Wernig; Brian J P Huntly; Titus J Boggon; Iwona Wlodarska; Jennifer J Clark; Sandra Moore; Jennifer Adelsperger; Sumin Koo; Jeffrey C Lee; Stacey Gabriel; Thomas Mercher; Alan D'Andrea; Stefan Fröhling; Konstanze Döhner; Peter Marynen; Peter Vandenberghe; Ruben A Mesa; Ayalew Tefferi; James D Griffin; Michael J Eck; William R Sellers; Matthew Meyerson; Todd R Golub; Stephanie J Lee; D Gary Gilliland
Journal:  Cancer Cell       Date:  2005-04       Impact factor: 31.743

4.  Thrombocytosis in childhood: a survey of 94 patients.

Authors:  K W Chan; Y Kaikov; L D Wadsworth
Journal:  Pediatrics       Date:  1989-12       Impact factor: 7.124

Review 5.  Polycythemia vera and essential thrombocythemia: 2012 update on diagnosis, risk stratification, and management.

Authors:  Ayalew Tefferi
Journal:  Am J Hematol       Date:  2012-03       Impact factor: 10.047

6.  Somatic mutations of calreticulin in myeloproliferative neoplasms.

Authors:  Thorsten Klampfl; Heinz Gisslinger; Ashot S Harutyunyan; Harini Nivarthi; Elisa Rumi; Jelena D Milosevic; Nicole C C Them; Tiina Berg; Bettina Gisslinger; Daniela Pietra; Doris Chen; Gregory I Vladimer; Klaudia Bagienski; Chiara Milanesi; Ilaria Carola Casetti; Emanuela Sant'Antonio; Virginia Ferretti; Chiara Elena; Fiorella Schischlik; Ciara Cleary; Melanie Six; Martin Schalling; Andreas Schönegger; Christoph Bock; Luca Malcovati; Cristiana Pascutto; Giulio Superti-Furga; Mario Cazzola; Robert Kralovics
Journal:  N Engl J Med       Date:  2013-12-10       Impact factor: 91.245

7.  Most pediatric patients with essential thrombocythemia show hypersensitivity to erythropoietin in vitro, with rare JAK2 V617F-positive erythroid colonies.

Authors:  Jitka Veselovska; Dagmar Pospisilova; Sona Pekova; Monika Horvathova; Renata Solna; Jana Cmejlova; Radek Cmejla; Monika Belickova; Vladimir Mihal; Jan Stary; Vladimir Divoky
Journal:  Leuk Res       Date:  2007-08-23       Impact factor: 3.156

8.  Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis.

Authors:  S Cortelazzo; G Finazzi; M Ruggeri; O Vestri; M Galli; F Rodeghiero; T Barbui
Journal:  N Engl J Med       Date:  1995-04-27       Impact factor: 91.245

9.  Secondary thrombocytosis.

Authors:  A J Vora; J S Lilleyman
Journal:  Arch Dis Child       Date:  1993-01       Impact factor: 3.791

10.  Markers of myeloproliferative diseases in childhood polycythemia vera and essential thrombocythemia.

Authors:  Luciana Teofili; Fiorina Giona; Maurizio Martini; Tonia Cenci; Francesco Guidi; Lorenza Torti; Giovanna Palumbo; Angela Amendola; Robin Foà; Luigi M Larocca
Journal:  J Clin Oncol       Date:  2007-03-20       Impact factor: 44.544
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  13 in total

1.  Mutational profile of childhood myeloproliferative neoplasms.

Authors:  A Karow; R Nienhold; P Lundberg; E Peroni; M C Putti; M L Randi; R C Skoda
Journal:  Leukemia       Date:  2015-07-30       Impact factor: 11.528

2.  Genetic analysis of five children with essential thrombocytosis identified mutations in cancer-associated genes with roles in transcriptional regulation.

Authors:  Nicole Kucine; Aaron D Viny; Raajit Rampal; Michael Berger; Nicholas Socci; Agnes Viale; James B Bussel; Ross L Levine; Franck Rapaport
Journal:  Haematologica       Date:  2016-03-18       Impact factor: 9.941

3.  Increased megakaryocytic proliferation, pro-platelet deposition and expression of fibrosis-associated factors in children with chronic myeloid leukaemia with bone marrow fibrosis.

Authors:  K Hussein; A Stucki-Koch; G Göhring; H Kreipe; M Suttorp
Journal:  Leukemia       Date:  2017-02-27       Impact factor: 11.528

Review 4.  Myeloproliferative Neoplasms in Children, Adolescents, and Young Adults.

Authors:  Nicole Kucine
Journal:  Curr Hematol Malig Rep       Date:  2020-04       Impact factor: 3.952

5.  Myeloproliferative Neoplasms in Children.

Authors:  Inga Hofmann
Journal:  J Hematop       Date:  2015-08-02       Impact factor: 0.196

Review 6.  Thrombocytosis in children and adolescents-classification, diagnostic approach, and clinical management.

Authors:  Clemens Stockklausner; C M Duffert; H Cario; R Knöfler; W Streif; A E Kulozik
Journal:  Ann Hematol       Date:  2021-03-12       Impact factor: 3.673

7.  Distinct molecular abnormalities underlie unique clinical features of essential thrombocythemia in children.

Authors:  R Fu; D Liu; Z Cao; S Zhu; H Li; H Su; L Zhang; F Xue; X Liu; X Zhang; T Cheng; R Yang; L Zhang
Journal:  Leukemia       Date:  2015-06-29       Impact factor: 11.528

8.  Thrombocytosis in children: Clinico-hematological profile from a single centre in Eastern India.

Authors:  Rachita Sarangi; Sarita Pradhan; Avantika Dhanawat; Rashmi Patanayak; Gautam Benia
Journal:  J Lab Physicians       Date:  2018 Jan-Mar

9.  A cross-sectional retrospective study to analyze the underlying causes and clinical characteristics of children with reactive thrombocytosis at a Korean tertiary medical center.

Authors:  Juhee Shin; Dong Hyun Lee; Nani Jung; Hee Joung Choi; Ye Jee Shim
Journal:  Blood Res       Date:  2018-09-28

10.  Extreme thrombocytosis is associated with critical illness and young age, but not increased thrombotic risk, in hospitalized pediatric patients.

Authors:  Christopher S Thom; Emily Echevarria; Ashley D Osborne; Leah Carr; Kathryn M Rubey; Elizabeth Salazar; Danielle Callaway; Thomas Pawlowski; Matthew Devine; Stacey Kleinman; Char Witmer; John Flibotte; Michele P Lambert
Journal:  J Thromb Haemost       Date:  2020-10-21       Impact factor: 16.036
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