| Literature DB >> 24687932 |
Abstract
Dermatomyositis is an autoimmune disease predominantly affecting skin and muscle. Its poorly understood pathogenesis is increasingly being linked to the overproduction of type 1 interferon-inducible gene transcripts and proteins. Mechanisms have been identified by which chronic sustained accumulation of these proteins might occur and thereby injure tissue in dermatomyositis.Entities:
Keywords: dermatomyositis; innate immune system; type 1 interferon
Mesh:
Substances:
Year: 2014 PMID: 24687932 DOI: 10.1002/path.4355
Source DB: PubMed Journal: J Pathol ISSN: 0022-3417 Impact factor: 7.996